P311 Antibody - #DF14359

(2)  
Product: P311 Antibody
Catalog: DF14359
Description: Rabbit polyclonal antibody to P311
Application: IHC IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 8kD(Calculated).
Uniprot: Q16612

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
P311 Antibody detects endogenous levels of total P311.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

3.1 gene; C5orf13; Chromosome 5 open reading frame 13; D4S114; Neuronal protein 3.1; Neuronal regeneration related protein; Neuronal regeneration related protein homolog (rat); Neuronal regeneration related protein homolog; NP311_HUMAN; NREP; P311; PRO1873; Protein p311; PTZ17; SEZ17;

Immunogens

Immunogen:

A synthesized peptide derived from Human P311.

Uniprot:

Q16612(NREP_HUMAN) >>Visit HPA database.

Gene(ID):
NREP(9315)
Expression:
Q16612 NREP_HUMAN:

Expressed in lung (at protein level).

Sequence:
MVYYPELFVWVSQEPFPNKDMEGRLPKGRLPVPKEVNRKKNDETNAASLTPLGSSELRSPRISYLHFF

Research Backgrounds

Function:

May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation.

PTMs:

Phosphorylated on Ser-59. Phosphorylation decreases stability and activity.

Subcellular Location:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in lung (at protein level).

Subunit Structure:

Interacts with the latency-associated peptides (LAP) of TGFB1 and TGFB2; the interaction results in a decrease in TGFB autoinduction (By similarity). Interacts with FLNA.

Restrictive clause

 

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