alpha 5 Defensin Antibody - #DF14360

(2)  
Product: alpha 5 Defensin Antibody
Catalog: DF14360
Description: Rabbit polyclonal antibody to alpha 5 Defensin
Application: IHC IF/ICC
Reactivity: Human
Mol.Wt.: 10kD(Calculated).
Uniprot: Q01523

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
alpha 5 Defensin Antibody detects endogenous levels of total alpha 5 Defensin.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

alpha 5; DEF5; DEF5_HUMAN; Defa; Defa29; DEFA5; Defcr29; Defcr5; Defensin 5; Defensin alpha 5; Defensin alpha 5 Paneth cell specific; Defensin alpha 5 preproprotein; Defensin; Enteric defensin; HD 5; HD5; HD5(20-94); HD5(63-94); MGC129728; RD 5;

Immunogens

Immunogen:

A synthesized peptide derived from Human alpha 5 Defensin.

Uniprot:

Q01523(DEF5_HUMAN) >>Visit HPA database.

Gene(ID):
DEFA5(1670)
Expression:
Q01523 DEF5_HUMAN:

Paneth cells of the small intestine (at protein level).

Sequence:
MRTIAILAAILLVALQAQAESLQERADEATTQKQSGEDNQDLAISFAGNGLSALRTSGSQARATCYCRTGRCATRESLSGVCEISGRLYRLCCR

Research Backgrounds

Function:

Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.

PTMs:

Glycosylated.

Subcellular Location:

Secreted. Cytoplasmic vesicle>Secretory vesicle.
Note: Peptides HD5(20-94), HD5(23-94) and HD5(29-94) are found within tissues, HD5(20-94) being the predominant intracellular form. Peptides HD5(56-94) and HD5(63-94) are found in the extracellular milieu, HD5(63-94) being the most abundant form.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Paneth cells of the small intestine (at protein level).

Subunit Structure:

Homodimer.

Family&Domains:

Belongs to the alpha-defensin family.

Restrictive clause

 

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