RAB3B Antibody - #DF14446

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Product: RAB3B Antibody
Catalog: DF14446
Description: Rabbit polyclonal antibody to RAB3B
Application: WB IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 25kD(Calculated).
Uniprot: P20337

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 100ul $280 In stock
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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
RAB3B Antibody detects endogenous levels of total RAB3B.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Brain antigen RAB3B; RAB3B; RAB3B member RAS oncogene family; RAB3B_HUMAN; ras related protein Rab 3B; Ras-related protein Rab-3B;

Immunogens

Immunogen:

A synthesized peptide derived from Human RAB3B.

Uniprot:

P20337(RAB3B_HUMAN) >>Visit HPA database.

Gene(ID):
RAB3B(5865)
Sequence:
MASVTDGKTGVKDASDQNFDYMFKLLIIGNSSVGKTSFLFRYADDTFTPAFVSTVGIDFKVKTVYRHEKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWATQIKTYSWDNAQVILVGNKCDMEEERVVPTEKGQLLAEQLGFDFFEASAKENISVRQAFERLVDAICDKMSDSLDTDPSMLGSSKNTRLSDTPPLLQQNCSC

Research Backgrounds

Function:

Protein transport. Probably involved in vesicular traffic (By similarity).

PTMs:

Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitor GDI2.

Subcellular Location:

Cell membrane>Lipid-anchor>Cytoplasmic side. Golgi apparatus.
Note: Colocalizes with GAS8/DRC4 in the Golgi apparatus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts with RIMS1, RIMS2, RPH3A and RPH3AL. The GTP-bound form interacts with GAS8/DRC4 (via coiled-coil domains) (By similarity). Interacts with GDI2, CHM and CHML; phosphorylation at Thr-86 disrupts these interactions.

Family&Domains:

Belongs to the small GTPase superfamily. Rab family.

Restrictive clause

 

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