TSPAN33 Antibody - #DF14701

(3)  
Product: TSPAN33 Antibody
Catalog: DF14701
Description: Rabbit polyclonal antibody to TSPAN33
Application: WB IHC IF/ICC
Reactivity: Human, Mouse
Mol.Wt.: 32kD(Calculated).
Uniprot: Q86UF1

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IF/ICC 1:100-1:500, IHC 1:50-1:200, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Polyclonal
Specificity:
TSPAN33 Antibody detects endogenous levels of TSPAN33.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

1300010A20Rik; AI035228; hPen; MGC30714; MGC50844; PEN; Penumbra; Proerythroblast new membrane; RGD1560915; Tetraspanin-33; TSN33; TSN33_HUMAN; Tspan-33; TSPAN33; Tspan33 tetraspanin 33;

Immunogens

Immunogen:

A synthesized peptide derived from human TSPAN33.

Uniprot:

Q86UF1(TSN33_HUMAN) >>Visit HPA database.

Gene(ID):
TSPAN33(340348)
Expression:
Q86UF1 TSN33_HUMAN:

Predominantly expressed in erythroblasts.

Sequence:
MARRPRAPAASGEEFSFVSPLVKYLLFFFNMLFWVISMVMVAVGVYARLMKHAEAALACLAVDPAILLIVVGVLMFLLTFCGCIGSLRENICLLQTFSLCLTAVFLLQLAAGILGFVFSDKARGKVSEIINNAIVHYRDDLDLQNLIDFGQKKFSCCGGISYKDWSQNMYFNCSEDNPSRERCSVPYSCCLPTPDQAVINTMCGQGMQAFDYLEASKVIYTNGCIDKLVNWIHSNLFLLGGVALGLAIPQLVGILLSQILVNQIKDQIKLQLYNQQHRADPWY

Research Backgrounds

Function:

Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity. Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7.

Subcellular Location:

Cell membrane>Multi-pass membrane protein. Cell junction>Adherens junction. Cytoplasm.
Note: Is localized to zonula adherens by PLEKHA7 by a PDZD11-dependent interaction.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Predominantly expressed in erythroblasts.

Subunit Structure:

Homodimer; disulfide-linked. Interacts (via extracellular domain) with ADAM10 (via extracellular domain). Interacts (via cytoplasmic domain) with PLEKHA7 (via WW domains); the interaction is dependent on PDZD11 being bound to PLEKHA7 and facilitates the docking of ADAM10 to zonula adherens.

Family&Domains:

Belongs to the tetraspanin (TM4SF) family.

Restrictive clause

 

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