MMEL1 Antibody - #DF14725

(2)  
Product: MMEL1 Antibody
Catalog: DF14725
Description: Rabbit polyclonal antibody to MMEL1
Application: IHC IF/ICC
Reactivity: Human
Mol.Wt.: 89kD(Calculated).
Uniprot: Q495T6

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
MMEL1 Antibody detects endogenous levels of MMEL1.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Mel transforming oncogene like 1; Membrane metallo endopeptidase like 1; Membrane metallo endopeptidase like 2; Membrane metallo-endopeptidase-like 1; Membrane metallo-endopeptidase-like 2; MMEL1; MMEL1_HUMAN; NEP2; NEP2(m); NEP2(s); NEPII; Neprilysin 2; Neprilysin II; Neprilysin Like 1; Neprilysin-2; Neprilysin-2 secreted; Neprilysin-like Protease beta; Neprilysin-like Protease gamma; NL1; NL2; SEP; soluble form; Soluble secreted endopeptidase;

Immunogens

Immunogen:

A synthesized peptide derived from human MMEL1.

Uniprot:

Q495T6(MMEL1_HUMAN) >>Visit HPA database.

Gene(ID):
MMEL1(79258)
Expression:
Q495T6 MMEL1_HUMAN:

Predominantly expressed in testis. Weakly expressed in brain, kidney and heart.

Sequence:
MGKSEGPVGMVESAGRAGQKRPGFLEGGLLLLLLLVTAALVALGVLYADRRGKQLPRLASRLCFLQEERTFVKRKPRGIPEAQEVSEVCTTPGCVIAAARILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYSIFDVLRDELEVILKAVLENSTAKDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILEVVGGWPVAMDRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREYYFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQEERHDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLSSVKIKLLPDEEVVVYGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRECVGYVNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFVETLDELGWMDEESKKKAQEKAMSIREQIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENSLQNLKVGAQRSLRKLREKVDPNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSWDLADEQNVNGFNTLGENIADNGGVRQAYKAYLKWMAEGGKDQQLPGLDLTHEQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW

Research Backgrounds

Function:

Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity).

PTMs:

N-glycosylated.

Subcellular Location:

Membrane>Single-pass type II membrane protein. Secreted.
Note: A secreted form produced by proteolytic cleavage also exists.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Predominantly expressed in testis. Weakly expressed in brain, kidney and heart.

Family&Domains:

Belongs to the peptidase M13 family.

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