SERTAD2 Antibody - #DF14785
| Product: | SERTAD2 Antibody |
| Catalog: | DF14785 |
| Description: | Rabbit polyclonal antibody to SERTAD2 |
| Application: | ELISA(peptide) |
| Reactivity: | Human, Mouse |
| Mol.Wt.: | 34kD(Calculated). |
| Uniprot: | Q14140 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
KIAA0127; MGC126688; MGC126690; Sei 2; Sei-2; Sei2; SERTA domain containing 2; SERTA domain-containing protein 2; SERTAD2; SRTD2_HUMAN; Transcriptional regulator interacting with the PHD bromodomain 2; Transcriptional regulator interacting with the PHD-bromodomain 2; Transcriptional regulator interacting with the PHS-bromodomain 2; TRIP Br2; TRIP-Br2;
Immunogens
A synthesized peptide derived from human SERTAD2.
- Q14140 SRTD2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLGKGGKRKFDEHEDGLEGKIVSPCDGPSKVSYTLQRQTIFNISLMKLYNHRPLTEPSLQKTVLINNMLRRIQEELKQEGSLRPMFTPSSQPTTEPSDSYREAPPAFSHLASPSSHPCDLGSTTPLEACLTPASLLEDDDDTFCTSQAMQPTAPTKLSPPALLPEKDSFSSALDEIEELCPTSTSTEAATAATDSVKGTSSEAGTQKLDGPQESRADDSKLMDSLPGNFEITTSTGFLTDLTLDDILFADIDTSMYDFDPCTSSSGTASKMAPVSADDLLKTLAPYSSQPVTPSQPFKMDLTELDHIMEVLVGS
Research Backgrounds
Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.
Polyubiquitinated, which promotes proteasomal degradation.
Nucleus. Cytoplasm.
Note: Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome.
Expressed in adipose tissue.
Interacts with XPO1; which mediates nuclear export. Interacts with TFDP1; modulates transactivation activity of TFDP1/E2F complexes.
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