WRNIP1 Antibody - #DF14889
| Product: | WRNIP1 Antibody |
| Catalog: | DF14889 |
| Description: | Rabbit polyclonal antibody to WRNIP1 |
| Application: | WB ELISA(peptide) |
| Reactivity: | Human, Mouse, Rat |
| Mol.Wt.: | 72kD(Calculated). |
| Uniprot: | Q96S55 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
ATPase WRNIP 1; ATPase WRNIP1; bA420G6.2; FLJ22526; Putative helicase RUVBL; RP11 420G6.2; Werner helicasae interacting protein 1; Werner helicasae interacting protein; Werner helicase interacting protein isoform 2; Werner helicase-interacting protein 1; WHIP; WRIP1_HUMAN; WRNIP 1; WRNIP; Wrnip1;
Immunogens
A synthesized peptide derived from human WRNIP1.
- Q96S55 WRIP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEVSGPEDDPFLSQLHQVQCPVCQQMMPAAHINSHLDRCLLLHPAGHAEPAAGSHRAGERAKGPSPPGAKRRRLSESSALKQPATPTAAESSEGEGEEGDDGGETESRESYDAPPTPSGARLIPDFPVARSSSPGRKGSGKRPAAAAAAGSASPRSWDEAEAQEEEEAVGDGDGDGDADADGEDDPGHWDADAAEAATAFGASGGGRPHPRALAAEEIRQMLQGKPLADTMRPDTLQDYFGQSKAVGQDTLLRSLLETNEIPSLILWGPPGCGKTTLAHIIASNSKKHSIRFVTLSATNAKTNDVRDVIKQAQNEKSFFKRKTILFIDEIHRFNKSQQDTFLPHVECGTITLIGATTENPSFQVNAALLSRCRVIVLEKLPVEAMVTILMRAINSLGIHVLDSSRPTDPLSHSSNSSSEPAMFIEDKAVDTLAYLSDGDARAGLNGLQLAVLARLSSRKMFCKKSGQSYSPSRVLITENDVKEGLQRSHILYDRAGEEHYNCISALHKSMRGSDQNASLYWLARMLEGGEDPLYVARRLVRFASEDIGLADPSALTQAVAAYQGCHFIGMPECEVLLAQCVVYFARAPKSIEVYSAYNNVKACLRNHQGPLPPVPLHLRNAPTRLMKDLGYGKGYKYNPMYSEPVDQEYLPEELRGVDFFKQRRC
Research Backgrounds
Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS.
Sumoylated with SUMO1 and SUMO2/3.
Nucleus. Cytoplasm.
Note: Colocalizes with WRN in granular structures in the nucleus.
Ubiquitously expressed.
Forms homooligomers, possibly octamers. Directly interacts with POLD1, POLD2 and POLD4. Interacts with the N-terminal domain of WRN (By similarity). Interacts (via UBZ4-type zinc finger) with monoubiquitin and polyubiquitin. Interacts with TRIM14 and PPP6C; these interactions positively regulate the RIG-I/DDX58 signaling pathway.
The UBZ4-type zinc finger binds ubiquitin.
Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
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