SLC14A1 Antibody - #DF14926

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Product: SLC14A1 Antibody
Catalog: DF14926
Description: Rabbit polyclonal antibody to SLC14A1
Application: IF/ICC
Reactivity: Human
Mol.Wt.: 43kD(Calculated).
Uniprot: Q13336

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
SLC14A1 Antibody detects endogenous levels of SLC14A1.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

blood group Kidd urea transporter; HsT1341; HUT11; JK; Kidd; kidd (JK) blood group urea transporter B1; RACH1; solute carrier family 14 (urea transporter) member 1 (Kidd blood group); urea transporter B1; Urea transporter erythrocyte; urea transporter JK glycoprotein; UT B1; UT1; UTE;

Immunogens

Immunogen:

A synthesized peptide derived from human SLC14A1.

Uniprot:

Q13336(UT1_HUMAN) >>Visit HPA database.

Gene(ID):
SLC14A1(6563)
Expression:
Q13336 UT1_HUMAN:

Detected in erythrocytes (at protein level). Erythrocytes.

Sequence:
MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKELANQLKDKPVVLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDLSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIYKMPLSKVTYPEENRIFYLQAKKRMVESPL

Research Backgrounds

Function:

Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.

Subcellular Location:

Cell membrane>Multi-pass membrane protein. Basolateral cell membrane>Multi-pass membrane protein.
Note: Restricted to the basolateral membrane in various portions of the urothelium.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Detected in erythrocytes (at protein level). Erythrocytes.

Subunit Structure:

Homotrimer; each subunit contains a pore through which urea permeates. Identified in a complex with STOM (By similarity).

Family&Domains:

Belongs to the urea transporter family.

Restrictive clause

 

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