ZNRF2 Antibody - #DF15043

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Product: ZNRF2 Antibody
Catalog: DF15043
Description: Rabbit polyclonal antibody to ZNRF2
Application: IHC IF/ICC
Reactivity: Human, Mouse
Mol.Wt.: 24kD(Calculated).
Uniprot: Q8NHG8

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Polyclonal
Specificity:
ZNRF2 Antibody detects endogenous levels of ZNRF2.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

E3 ubiquitin-protein ligase ZNRF2; Protein Ells2; RING finger protein 202; RNF202; Zinc/RING finger protein 2; Znrf2; ZNRF2_HUMAN;

Immunogens

Immunogen:

A synthesized peptide derived from human ZNRF2.

Uniprot:

Q8NHG8(ZNRF2_HUMAN) >>Visit HPA database.

Gene(ID):
ZNRF2(223082)
Expression:
Q8NHG8 ZNRF2_HUMAN:

Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.

Sequence:
MGAKQSGPAAANGRTRAYSGSDLPSSSSGGANGTAGGGGGARAAAAGRFPAQVPSAHQPSASGGAAAAAAAPAAPAAPRSRSLGGAVGSVASGARAAQSPFSIPNSSSGPYGSQDSVHSSPEDGGGGRDRPVGGSPGGPRLVIGSLPAHLSPHMFGGFKCPVCSKFVSSDEMDLHLVMCLTKPRITYNEDVLSKDAGECAICLEELQQGDTIARLPCLCIYHKGCIDEWFEVNRSCPEHPSD

Research Backgrounds

Function:

May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Subcellular Location:

Endosome membrane>Peripheral membrane protein. Lysosome membrane>Peripheral membrane protein. Cell junction>Synapse>Presynaptic cell membrane>Peripheral membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.

Subunit Structure:

Interacts with UBE2N.

Family&Domains:

The RING-type zinc finger domain is required for E3 ligase activity.

Restrictive clause

 

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