SHBG Antibody - #DF15075

(3)  
Product: SHBG Antibody
Catalog: DF15075
Description: Rabbit polyclonal antibody to SHBG
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 44kD(Calculated).
Uniprot: P04278

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
SHBG Antibody detects endogenous levels of SHBG.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

ABP; Androgen binding protein; SBP; Sex hormone-binding globulin; Sex steroid binding protein; Sex steroid-binding protein; SHBG; SHBG_HUMAN; TeBG; Testis specific androgen binding protein; Testis-specific androgen-binding protein; Testosterone binding beta globulin; Testosterone estradiol binding globulin; Testosterone estrogen binding globulin; Testosterone-estradiol-binding globulin; Testosterone-estrogen-binding globulin;

Immunogens

Immunogen:

A synthesized peptide derived from human SHBG.

Uniprot:

P04278(SHBG_HUMAN) >>Visit HPA database.

Gene(ID):
SHBG(6462)
Expression:
P04278 SHBG_HUMAN:

Isoform 1 and isoform 2 are present in liver and testis.

Sequence:
MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPGLDLPLVLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTSFCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGNGTDASH

Research Backgrounds

Function:

Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.

PTMs:

Variant Asn-356 contains one N-linked (GlcNAc...) at position 356.

Subcellular Location:

Secreted.
Note: In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Isoform 1 and isoform 2 are present in liver and testis.

Subunit Structure:

Homodimer.

Restrictive clause

 

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