ELAVL3 Antibody - #DF15224

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Product: ELAVL3 Antibody
Catalog: DF15224
Description: Rabbit polyclonal antibody to ELAVL3
Application: IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 40kD(Calculated).
Uniprot: Q14576

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
ELAVL3 Antibody detects endogenous levels of ELAVL3.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

ELAV (embryonic lethal abnormal vision Drosophila) like 3 (Hu antigen C); ELAV like protein 3; ELAV-like protein 3; ELAV3_HUMAN; Elavl3; Embryonic lethal, abnormal vision, drosophila, homolog-like; Hu antigen C; Hu-antigen C; HuC; HUCL; MGC20653; Paraneoplastic cerebellar degeneration associated antigen; Paraneoplastic cerebellar degeneration-associated antigen; Paraneoplastic limbic encephalitis antigen 21; PLE21;

Immunogens

Immunogen:

A synthesized peptide derived from human ELAVL3.

Uniprot:

Q14576(ELAV3_HUMAN) >>Visit HPA database.

Gene(ID):
ELAVL3(1995)
Expression:
Q14576 ELAV3_HUMAN:

Brain specific.

Sequence:
MVTQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGERVLQVSFKTSKQHKA

Research Backgrounds

Function:

RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance (By similarity). Plays a role in the stabilization of GAP43 mRNA and in spatial learning (By similarity).

Tissue Specificity:

Brain specific.

Subunit Structure:

Interacts with MAP1B light chain LC1.

Family&Domains:

RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences (By similarity).

Belongs to the RRM elav family.

Restrictive clause

 

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For Research Use Only.
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