RABAC1 Antibody - #DF15474

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Product: RABAC1 Antibody
Catalog: DF15474
Description: Rabbit polyclonal antibody to RABAC1
Application: IHC IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 21kD(Calculated).
Uniprot: Q9UI14

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
RABAC1 Antibody detects endogenous levels of RABAC1.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

PRA1 domain family 1; PRA1 family protein 1; PRAF1; PRAF1_HUMAN; prenylated Rab acceptor 1; Prenylated Rab acceptor protein 1; Rab acceptor 1 (prenylated); RABAC1; YIP3;

Immunogens

Immunogen:

A synthesized peptide derived from human RABAC1.

Uniprot:

Q9UI14(PRAF1_HUMAN) >>Visit HPA database.

Gene(ID):
RABAC1(10567)
Expression:
Q9UI14 PRAF1_HUMAN:

Ubiquitous. Strongest expression found in placenta, pituitary gland, kidney, lung and stomach.

Sequence:
MAAQKDQQKDAEAEGLSGTTLLPKLIPSGAGREWLERRRATIRPWSTFVDQQRFSRPRNLGELCQRLVRNVEYYQSNYVFVFLGLILYCVVTSPMLLVALAVFFGACYILYLRTLESKLVLFGREVSPAHQYALAGGISFPFFWLAGAGSAVFWVLGATLVVIGSHAAFHQIEAVDGEELQMEPV

Research Backgrounds

Function:

General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI.

Subcellular Location:

Cell membrane>Multi-pass membrane protein. Cytoplasm. Golgi apparatus. Cytoplasmic vesicle>Secretory vesicle>Synaptic vesicle.
Note: According to some authors, it is an integral membrane protein, while others showed that it is cytoplasmic and membrane-associated to Golgi and synaptic vesicles.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Ubiquitous. Strongest expression found in placenta, pituitary gland, kidney, lung and stomach.

Subunit Structure:

Homodimer. Interacts with VAMP2 (synaptobrevin-2), GDI1, and PCLO (By similarity). Interacts specifically with prenylated Rab proteins; strongly with RAB4B, RAB5A and RAB5C, and weakly with RAB4A, RAB6, RAB7A, RAB17 and RAB22. Interacts with NDRG1.

Family&Domains:

Belongs to the PRA1 family.

Restrictive clause

 

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