RYBP Antibody - #DF15548
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
2410018J24Rik; AAP 1; AAP1; APAP 1; APAP-1; APAP1; Apoptin associating protein 1; Apoptin-associating protein 1; cb337; Death effector domain associated factor; Death effector domain-associated factor; Death effector domain-associated factor B; DED associated factor; DED-associated factor; DED-associated factor B; DEDAF; MGC62213; RING1 and YY1 binding protein a; RING1 and YY1 binding protein; RING1 and YY1-binding protein; RING1 and YY1-binding protein B; Ring1 interactor RYBP; RYBP; RYBP_HUMAN; rybpa; wu:fi34f03; YEAF 1; YEAF1; YY1 and E4TF1 associated factor 1; YY1 and E4TF1-associated factor 1; YY1- and E4TF1/GABP-associated factor 1; zgc:153842;
Immunogens
A synthesized peptide derived from human RYBP.
Down-regulated in breast cancer tissues and in several breast cancer cell lines (at protein level) (PubMed:27748911). Widely expressed with highest levels in lymphoid tissues and placenta.
- Q8N488 RYBP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTMGDKKSPTRPKRQAKPAADEGFWDCSVCTFRNSAEAFKCSICDVRKGTSTRKPRINSQLVAQQVAQQYATPPPPKKEKKEKVEKQDKEKPEKDKEISPSVTKKNTNKKTKPKSDILKDPPSEANSIQSANATTKTSETNHTSRPRLKNVDRSTAQQLAVTVGNVTVIITDFKEKTRSSSTSSSTVTSSAGSEQQNQSSSGSESTDKGSSRSSTPKGDMSAVNDESF
Research Backgrounds
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3.
Monoubiquitinated.
Nucleus. Cytoplasm. Nucleus>Nucleoplasm.
Note: Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity).
Down-regulated in breast cancer tissues and in several breast cancer cell lines (at protein level). Widely expressed with highest levels in lymphoid tissues and placenta.
Intrinsically unstructured in the absence of binding partners. Folds upon binding to DNA or RNF2 (By similarity).
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