BEX1 Antibody | Affinity Biosciences

Product:	BEX1 Antibody
Catalog:	DF15606
Description:	Rabbit polyclonal antibody to BEX1
Application:	ELISA(peptide)
Reactivity:	Human
Mol.Wt.:	15kD(Calculated).
Uniprot:	Q9HBH7

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Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific.

Size	Price	Inventory
100ul	$280	In stock
200ul	$350	In stock

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Related Downloads

MS Report

HPLC Report

MSDS

Data Sheet

COA

Protocols

WB Handbook

IHC Protocol

IF/ICC Protocol

Product Info

Source:

Rabbit

Application:

ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:

Human

Clonality:

Polyclonal

Specificity:

BEX1 Antibody detects endogenous levels of BEX1.

Conjugate:

Unconjugated.

Purification:

The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Storage:

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Alias:

Fold/Unfold

BEX2; Brain expressed X linked 1; HBEX2; Protein BEX1; Reduced expression protein 3; REX 3; REX3;

Immunogens

Immunogen:

A synthesized peptide derived from human BEX1.

Uniprot:

Q9HBH7(BEX1_HUMAN) >>Visit HPA database.

Gene(ID):

BEX1(55859)

Expression:

Q9HBH7 BEX1_HUMAN:

Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone marrow. Highly expressed in acute myeloid leukemia.

Sequence:

Q9HBH7 BEX1_HUMAN:
Protein BLAST With
NCBI/
ExPASy/
Uniprot

MESKEKRAVNSLSMENANQENEEKEQVANKGEPLALPLDAGEYCVPRGNRRRFRVRQPILQYRWDMMHRLGEPQARMREENMERIGEEVRQLMEKLREKQLSHSLRAVSTDPPHHDHHDEFCLMP

Research Backgrounds

Q9HBH7_BEX1_HUMAN

Function:

Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity).

PTMs:

Phosphorylated. Phosphorylation of Ser-102 protects it from the proteasome (By similarity).

Ubiquitinated. Degraded by the proteasome (By similarity).

Subcellular Location:

Nucleus. Cytoplasm.
Note: Shuttles between the cytoplasm and the nucleus.

Tissue Specificity:

Subunit Structure:

Interacts with neurotrophin receptor p75NTR/NGFR. Interacts with OMP (By similarity).

Family&Domains:

Belongs to the BEX family.

Restrictive clause

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.

BEX1 Antibody - #DF15606