AKAP7 Antibody - #DF15787

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Product: AKAP7 Antibody
Catalog: DF15787
Description: Rabbit polyclonal antibody to AKAP7
Application: IF/ICC
Reactivity: Human
Mol.Wt.: 11kD(Calculated).
Uniprot: O43687

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 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
AKAP7 Antibody detects endogenous levels of AKAP7.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

Immunogens

Immunogen:

A synthesized peptide derived from human AKAP7.

Uniprot:

O43687(AKA7A_HUMAN) >>Visit HPA database.

Gene(ID):
AKAP7(9465)
Expression:
O43687 AKA7A_HUMAN:

Expressed in brain, heart, lung, pancreas and skeletal muscle.

Sequence:
MGQLCCFPFSRDEGKISELESSSSAVLQRYSKDIPSWSSGEKNGGEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKPGEGSSVKTEAADQNGNDNENNRK

Research Backgrounds

Function:

Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.

Subcellular Location:

Lateral cell membrane>Lipid-anchor.
Note: Targeted predominantly to the lateral membrane.

Apical cell membrane>Lipid-anchor.
Note: Targeted predominantly to the apical membrane.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in brain, heart, lung, pancreas and skeletal muscle.

Subunit Structure:

Binds cAMP-dependent protein kinase (PKA). Interacts with PRKCA; only the cytoplasmic form is capable of interacting with PRKCA.

Restrictive clause

 

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