AGTRAP Antibody - #DF15908

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Product: AGTRAP Antibody
Catalog: DF15908
Description: Rabbit polyclonal antibody to AGTRAP
Application: IHC
Reactivity: Human
Mol.Wt.: 17kD(Calculated).
Uniprot: Q6RW13

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
AGTRAP Antibody detects endogenous levels of AGTRAP.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Agtrap; Angiotensin II receptor associated protein; Angiotensin II type I receptor associated protein; AT1 receptor-associated protein; ATI receptor associated protein; ATRAP; ATRAP_HUMAN; MGC29646; OTTHUMP00000002269; OTTHUMP00000002270; OTTHUMP00000002271; Type 1 angiotensin II receptor associated protein; Type-1 angiotensin II receptor-associated protein;

Immunogens

Immunogen:

A synthesized peptide derived from human AGTRAP.

Uniprot:

Q6RW13(ATRAP_HUMAN) >>Visit HPA database.

Gene(ID):
AGTRAP(57085)
Expression:
Q6RW13 ATRAP_HUMAN:

Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.

Sequence:
MELPAVNLKVILLGHWLLTTWGCIVFSGSYAWANFTILALGVWAVAQRDSIDAISMFLGGLLATIFLDIVHISIFYPRVSLTDTGRFGVGMAILSLLLKPLSCCFVYHMYRERGGELLVHTGFLGSSQDRSAYQTIDSAEAPADPFAVPEGRSQDARGY

Research Backgrounds

Function:

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.

Subcellular Location:

Endoplasmic reticulum membrane>Multi-pass membrane protein. Golgi apparatus membrane>Multi-pass membrane protein. Cytoplasmic vesicle membrane>Multi-pass membrane protein.
Note: Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.

Subunit Structure:

Interacts with RACK1, and with the C-terminal region of AGTR1.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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