AFfirm™ CD34 Mouse Monoclonal Antibody - #BF8200
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Fold/Unfold
CD34; CD34 antigen; CD34 molecule; CD34_HUMAN; Cluster designation 34; Hematopoietic progenitor cell antigen CD34; HPCA1; Mucosialin; OTTHUMP00000034733; OTTHUMP00000034734;
Immunogens
Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.
- P28906 CD34_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLVRRGARAGPRMPRGWTALCLLSLLPSGFMSLDNNGTATPELPTQGTFSNVSTNVSYQETTTPSTLGSTSLHPVSQHGNEATTNITETTVKFTSTSVITSVYGNTNSSVQSQTSVISTVFTTPANVSTPETTLKPSLSPGNVSDLSTTSTSLATSPTKPYTSSSPILSDIKAEIKCSGIREVKLTQGICLEQNKTSSCAEFKKDRGEGLARVLCGEEQADADAGAQVCSLLLAQSEVRPQCLLLVLANRTEISSKLQLMKKHQSDLKKLGILDFTEQDVASHQSYSQKTLIALVTSGALLAVLGITGYFLMNRRSWSPTGERLGEDPYYTENGGGQGYSSGPGTSPEAQGKASVNRGAQENGTGQATSRNGHSARQHVVADTEL
PTMs - P28906 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S198 | Phosphorylation | Uniprot | |
| K268 | Acetylation | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| Y286 | Phosphorylation | Uniprot | |
| Y329 | Phosphorylation | Uniprot | |
| Y330 | Phosphorylation | Uniprot | |
| T331 | Phosphorylation | Uniprot | |
| Y339 | Phosphorylation | Uniprot | |
| S341 | Phosphorylation | Uniprot | |
| S346 | Phosphorylation | P31751 (AKT2) | Uniprot |
| S354 | Phosphorylation | Uniprot |
Research Backgrounds
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
Highly glycosylated.
Phosphorylated on serine residues by PKC.
Membrane>Single-pass type I membrane protein.
Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.
Belongs to the CD34 family.
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