AFfirm™ EGR2 Mouse Monoclonal Antibody - #BF9313

Product: EGR2 Mouse Monoclonal Antibody
Catalog: BF9313
Description: Mouse monoclonal antibody to EGR2
Application: WB
Reactivity: Human
Prediction: Mouse, Rat, Pig, Horse, Sheep, Rabbit, Dog, Xenopus
Mol.Wt.: 50kDa; 50kD(Calculated).
Uniprot: P11161

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 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Mouse
Application:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Monoclonal [AFfirm9313]
Specificity:
EGR2 Mouse Monoclonal Antibody detects endogenous levels of total EGR2.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

AT225; AT591; CMT1D; CMT4E; E3 SUMO-protein ligase EGR2; Early growth response 1; Early growth response 2; Early growth response protein 1; Early growth response protein 2; EGR1; EGR2; G0S30; KROX-24; KROX20; Nerve growth factor-induced protein A; NGFI A; NGFI-A; TIS8; Transcription factor ETR103; Transcription factor Zif268; ZIF-268; Zinc finger protein 225; Zinc finger protein Krox-20; Zinc finger protein Krox-24; ZNF225;

Immunogens

Immunogen:
Uniprot:

P11161(EGR2_HUMAN) >>Visit HPA database.

Gene(ID):
EGR2(1959)
Description:
The early growth response protein 2 is a transcription factor with three tandem C2H2-type zinc fingers. Mutations in this gene are associated with the autosomal dominant Charcot-Marie-Tooth disease, type 1.
Sequence:
MMTAKAVDKIPVTLSGFVHQLSDNIYPVEDLAATSVTIFPNAELGGPFDQMNGVAGDGMINIDMTGEKRSLDLPYPSSFAPVSAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGILQGVTSPASTTASSSVTSASPNPLATGPLGVCTMSQTQPDLDHLYSPPPPPPPYSGCAGDLYQDPSAFLSAATTSTSSSLAYPPPPSYPSPKPATDPGLFPMIPDYPGFFPSQCQRDLHGTAGPDRKPFPCPLDTLRVPPPLTPLSTIRNFTLGGPSAGVTGPGASGGSEGPRLPGSSSAAAAAAAAAAYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSASVPAPSTASCSGGVQPGGTLCSSNSSSLGGGPLAPCSSRTRTP

PTMs - P11161 As Substrate

Site PTM Type Enzyme
S70 Phosphorylation
Y75 Phosphorylation
S77 Phosphorylation
R257 Methylation
T263 Phosphorylation
R293 Methylation
T391 Phosphorylation
T393 Phosphorylation

Research Backgrounds

Function:

Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4.

E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity.

PTMs:

Ubiquitinated by WWP2 leading to proteasomal degradation.

Subcellular Location:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts with HCFC1. Interacts with WWP2. Interacts with UBC9.

Family&Domains:

Belongs to the EGR C2H2-type zinc-finger protein family.

Research Fields

· Human Diseases > Infectious diseases: Viral > Hepatitis B.

· Human Diseases > Infectious diseases: Viral > HTLV-I infection.

· Human Diseases > Cancers: Overview > Viral carcinogenesis.

Restrictive clause

 

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