AFfirm™ TBX22 Mouse Monoclonal Antibody - #BF9315
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Protocols
Product Info
Source:
Mouse
Application:
WB 1:500-1:3000
*The optimal dilutions should be determined by the end user.
*Tips:
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Reactivity:
Human
Clonality:
Monoclonal [AFfirm9315]
Specificity:
TBX22 Mouse Monoclonal Antibody detects endogenous levels of total TBX22.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:
Fold/Unfold
ABERS; CLPA; CPX; D230020M15Rik; dJ795G23.1; T box 22; T box protein 22; T box transcription factor TBX22; T-box protein 22; T-box transcription factor TBX22; Tbx22; TBX22_HUMAN; TBXX;
Immunogens
Immunogen:
Uniprot:
Gene(ID):
Expression:
Description:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis.
Sequence:
- Q9Y458 TBX22_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALSSRARAFSVEALVGRPSKRKLQDPIQAEQPELREKKGGEEEEERRSSAAGKSEPLEKQPKTEPSTSASSGCGSDSGYGNSSESLEEKDIQMELQGSELWKRFHDIGTEMIITKAGRRMFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYVYHSSQWMVAGNTDHLCIIPRFYVHPDSPCSGETWMRQIISFDRMKLTNNEMDDKGHIILQSMHKYKPRVHVIEQGSSVDLSQIQSLPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFAKGFRDTGRNRGVLDGLLETYPWRPSFTLDFKTFGADTQSGSSGSSPVTSSGGAPSPLNSLLSPLCFSPMFHLPTSSLGMPCPEAYLPNVNLPLCYKICPTNFWQQQPLVLPAPERLASSNSSQSLAPLMMEVPMLSSLGVTNSKSGSSEDSSDQYLQAPNSTNQMLYGLQSPGNIFLPNSITPEALSCSFHPSYDFYRYNFSMPSRLISGSNHLKVNDDSQVSFGEGKCNHVHWYPAINHYL
PTMs - Q9Y458 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K63 | Sumoylation | Uniprot | |
| T68 | Phosphorylation | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| S72 | Phosphorylation | Uniprot | |
| S78 | Phosphorylation | Uniprot | |
| S83 | Phosphorylation | Uniprot | |
| S84 | Phosphorylation | Uniprot | |
| S86 | Phosphorylation | Uniprot | |
| Y138 | Phosphorylation | Uniprot | |
| T243 | Phosphorylation | Uniprot | |
| T268 | Phosphorylation | Uniprot | |
| K271 | Sumoylation | Uniprot |
Research Backgrounds
Function:
Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis.
Subcellular Location:
Nucleus.
Tissue Specificity:
Seems to be expressed at a low level.
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