SKIL Antibody - #DF3088
Product: | SKIL Antibody |
Catalog: | DF3088 |
Description: | Rabbit polyclonal antibody to SKIL |
Application: | WB IF/ICC |
Reactivity: | Human, Mouse, Rat |
Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
Mol.Wt.: | 77 KD; 77kD(Calculated). |
Uniprot: | P12757 |
RRID: | AB_2835471 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3088, RRID:AB_2835471.
Fold/Unfold
OTTHUMP00000213557; OTTHUMP00000213591; OTTHUMP00000213592; OTTHUMP00000213595; SKI like; SKI like oncogene; Ski like protein; SKI like proto oncogene; Ski related oncogene; Ski related oncogene snoN; Ski related protein; Ski-like protein; Ski-related oncogene; Ski-related protein; SKIL; SKIL_HUMAN; SNO; SnoA; SnoI; SnoN;
Immunogens
Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle.
- P12757 SKIL_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEAPVETDGEHVKRTCTSVPETLHLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTAKE
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P12757 As Substrate
Site | PTM Type | Enzyme | Source |
---|---|---|---|
T6 | Phosphorylation | Uniprot | |
S26 | Phosphorylation | Uniprot | |
K50 | Sumoylation | Uniprot | |
K70 | Ubiquitination | Uniprot | |
K249 | Ubiquitination | Uniprot | |
K256 | Ubiquitination | Uniprot | |
K342 | Ubiquitination | Uniprot | |
K383 | Sumoylation | Uniprot | |
K423 | Ubiquitination | Uniprot | |
T426 | Phosphorylation | Uniprot | |
K432 | Acetylation | Uniprot | |
K440 | Acetylation | Uniprot | |
K440 | Ubiquitination | Uniprot | |
K446 | Ubiquitination | Uniprot | |
K449 | Ubiquitination | Uniprot | |
S452 | Phosphorylation | Uniprot | |
S457 | Phosphorylation | Uniprot | |
K463 | Acetylation | Uniprot | |
K487 | Methylation | Uniprot | |
K489 | Sumoylation | Uniprot | |
S490 | Phosphorylation | Uniprot | |
S514 | Phosphorylation | Uniprot | |
K527 | Sumoylation | Uniprot | |
K540 | Ubiquitination | Uniprot | |
K552 | Ubiquitination | Uniprot | |
K580 | Ubiquitination | Uniprot | |
K601 | Ubiquitination | Uniprot | |
K612 | Ubiquitination | Uniprot | |
K625 | Ubiquitination | Uniprot |
Research Backgrounds
May have regulatory role in cell division or differentiation in response to extracellular signals.
Ubiquitinated by RNF111 and RNF165, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling.
Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle.
Interacts with CPNE4 (via VWFA domain) (By similarity). Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1.
Belongs to the SKI family.
Research Fields
· Cellular Processes > Cellular community - eukaryotes > Signaling pathways regulating pluripotency of stem cells. (View pathway)
References
Application: WB Species: Mouse Sample:
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