Product: TBX1 Antibody
Catalog: AF0327
Description: Rabbit polyclonal antibody to TBX1
Application: WB IF/ICC
Reactivity: Human
Mol.Wt.: 43kDa; 43kD(Calculated).
Uniprot: O43435
RRID: AB_2833490

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 100ul $280 In stock
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Product Info

Source:
Rabbit
Application:
WB 1:500-1:3000, IF/ICC: 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
TBX1 Antibody detects endogenous levels of total TBX1.
RRID:
AB_2833490
Cite Format: Affinity Biosciences Cat# AF0327, RRID:AB_2833490.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Brachyury; CAFS; CTHM; DGCR; DGS; DORV; T box; T box 1; T box 1 transcription factor; T box 1 transcription factor C; T box protein 1; T box transcription factor TBX 1; T box transcription factor TBX1; T-box protein 1; T-box transcription factor TBX1; TBX 1; TBX 1C; tbx1; TBX1_HUMAN; TBX1C; Testis specific T box protein; Testis-specific T-box protein; TGA; VCFS;

Immunogens

Immunogen:

A synthesized peptide derived from human TBX1, corresponding to a region within C-terminal amino acids.

Uniprot:
Gene(ID):
Description:
TBX1 Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries. 3 isoforms of the human protein are produced by alternative splicing.
Sequence:
MHFSTVTRDMEAFTASSLSSLGAAGGFPGAASPGADPYGPREPPPPPPRYDPCAAAAPGAPGPPPPPHAYPFAPAAGAATSAAAEPEGPGASCAAAAKAPVKKNAKVAGVSVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVPVDDKRYRYAFHSSSWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDPRKDSEKYAEENFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHRPGALPLMSAFARSRNPVASPTQPSGTEKGGHVLKDKEVKAETSRNTPEREVELLRDAGGCVNLGLPCPAECQPFNTQGLVAGRTAGDRLC

PTMs - O43435 As Substrate

Site PTM Type Enzyme
T142 Phosphorylation
K202 Ubiquitination
Y255 Phosphorylation
T282 Phosphorylation
S327 Phosphorylation

Research Backgrounds

Function:

Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries (By similarity).

Subcellular Location:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts with DSCR6.

References

1). Sun L et al. Establishment of an induced pluripotent stem cell line (SAHGMUi001-A) from a patient with Netherton syndrome carrying SPINK5 mutation. Stem Cell Research 2020 May;45:101833. (PubMed: 32416580) [IF=1.2]

2). Wang L et al. Generation and characterization of an induced pluripotent stem cell line (ZSYYDNi001-A) from a patient with Duchenne muscular dystrophy carrying exon 51 deletion in the DMD gene. Stem Cell Research 2021 Sep 30;56:102553. (PubMed: 34619646) [IF=1.2]

Application: IF/ICC    Species: Human    Sample:

Fig. 1. Characterization of the induced pluripotent stem cell line.

Restrictive clause

 

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