PPBP Recombinant Rabbit mAb - #BF3692

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Product: PPBP Recombinant Rabbit mAb
Catalog: BF3692
Description: Rabbit monoclonal antibody to PPBP
Application: WB IHC
Reactivity: Human, Rat
Mol.Wt.: 11 kDa(Observed); 11kD(Calculated).
Uniprot: P02776

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 100ul $280 In stock

Lead Time: Same day delivery

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit IgG
Application:
WB 1:1000-1:5000, IHC 1:100-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Rat
Clonality:
Monoclonal [ReFirm23139]
Specificity:
PPBP Recombinant Rabbit mAb detects endogenous levels of PPBP.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

C-X-C motif chemokine 4;Chemokine (C X C motif) ligand 4;Chemokine (CXC motif) ligand 4;chemokine ligand 4;CXCL 4;CXCL4;Iroplact;MGC138298;Oncostatin A;Oncostatin-A;OncostatinA;PF 4;PF-4;PF4;Pf4a;Platelet factor 4;PLF4_HUMAN;SCYB 4;SCYB4;short form;Small inducible cytokine subfamily B;Small inducible cytokine subfamily member 4 antibody

Immunogens

Immunogen:

A synthetic peptide from human PPBP

Uniprot:

P02776(PLF4_HUMAN) >>Visit HPA database.

Gene(ID):
PF4(5196)
Description:
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis,angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum.
Sequence:
MSSAAGFCASRPGLLFLGLLLLPLVVAFASAEAEEDGDLQCLCVKTTSQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES

Research Backgrounds

Function:

Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.

Subcellular Location:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Family&Domains:

Belongs to the intercrine alpha (chemokine CxC) family.

Research Fields

· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction.   (View pathway)

· Organismal Systems > Immune system > Chemokine signaling pathway.   (View pathway)

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For Research Use Only.
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