CRP Recombinant Rabbit mAb - #BF3713

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Product: CRP Recombinant Rabbit mAb
Catalog: BF3713
Description: Rabbit monoclonal antibody to CRP
Application: WB IHC
Reactivity: Human
Mol.Wt.: 25 kDa(Observed); 25kD(Calculated).
Uniprot: P02741

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 100ul $280 In stock

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit IgG
Application:
WB 1:1000, IHC 1:200-1:2000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Monoclonal [ReFirm23160]
Specificity:
CRP Recombinant Rabbit mAb detects endogenous levels of CRP.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Pentraxin 1, short; C reactive protein; C reactive protein pentraxin related; C-reactive protein(1-205); CRP; CRP_HUMAN; MGC88244; Pentraxin 1; PTX 1; PTX1;

Immunogens

Immunogen:

A synthetic peptide from human CRP

Uniprot:

P02741(CRP_HUMAN) >>Visit HPA database.

Gene(ID):
CRP(1401)
Expression:
P02741 CRP_HUMAN:

Found in plasma.

Description:
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently,the level of this protein in plasma increases greatly during acute phase response to tissue injury,infection,or other inflammatory stimuli.
Sequence:
MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWESASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP

Research Backgrounds

Function:

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Subcellular Location:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Found in plasma.

Family&Domains:

Belongs to the pentraxin family.

Restrictive clause

 

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