Prealbumin Recombinant Rabbit mAb - #BF3871

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Product: Prealbumin Recombinant Rabbit mAb
Catalog: BF3871
Description: Rabbit monoclonal antibody to Prealbumin
Application: WB IHC
Reactivity: Human
Mol.Wt.: 15,45kD(Observed); 16kD(Calculated).
Uniprot: P02766

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 100ul $280 In stock

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Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit IgG
Application:
WB 1:1000-1:5000, IHC 1:50-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Monoclonal [ReFirm23318]
Specificity:
Prealbumin Recombinant Rabbit mAb detects endogenous levels of Prealbumin.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Amyloid polyneuropathy; Amyloidosis I; ATTR; Carpal tunnel syndrome 1; CTS; CTS1; Dysprealbuminemic euthyroidal hyperthyroxinemia; Dystransthyretinemic hyperthyroxinemia; Epididymis luminal protein 111; HEL111; HsT2651; PALB; Prealbumin amyloidosis type I; Prealbumin; Prealbumin Thyroxine-binding; Senile systemic amyloidosis; TBPA; Thyroxine binding prealbumin; Transthyretin; TTHY_HUMAN; TTR; TTR protein;

Immunogens

Immunogen:

A synthetic peptide from human Prealbumin

Uniprot:

P02766(TTHY_HUMAN) >>Visit HPA database.

Gene(ID):
TTR(7276)
Expression:
P02766 TTHY_HUMAN:

Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.

Description:
This gene encodes one of the three prealbumins,which include alpha-1-antitrypsin,transthyretin and orosomucoid. The encoded protein,transthyretin,is a homo-tetrameric carrier protein,which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis,nerve regeneration,autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition,predominantly affecting peripheral nerves or the heart,while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases,including amyloidotic polyneuropathy,euthyroid hyperthyroxinaemia,amyloidotic vitreous opacities,cardiomyopathy,oculoleptomeningeal amyloidosis,meningocerebrovascular amyloidosis and carpal tunnel syndrome.
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE

Research Backgrounds

Function:

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

PTMs:

Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYL-TTR 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway.

Subcellular Location:

Secreted. Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.

Family&Domains:

Each monomer has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel.

Belongs to the transthyretin family.

Research Fields

· Organismal Systems > Endocrine system > Thyroid hormone synthesis.

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