CRABP2 Recombinant Rabbit mAb - #BF3920

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Product: CRABP2 Recombinant Rabbit mAb
Catalog: BF3920
Description: Rabbit monoclonal antibody to CRABP2
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 14 kDa(Observed); 16kD(Calculated).
Uniprot: P29373

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit IgG
Application:
WB 1:1000, IHC 1:200-1:1000, ICC
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human, Mouse, Rat
Clonality:
Monoclonal [ReFirm23367]
Specificity:
CRABP2 Recombinant Rabbit mAb detects endogenous levels of CRABP2.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Cellular retinoic acid binding protein 2; Cellular retinoic acid binding protein II; Cellular retinoic acid-binding protein 2; Cellular retinoic acid-binding protein II; CRABP II; CRABP-II; Crabp2; CRABPII; RABP2_HUMAN; RBP6; Rretinoic acid-binding protein, cellular, type II;

Immunogens

Immunogen:

A synthetic peptide from human CRABP2

Uniprot:

P29373(RABP2_HUMAN) >>Visit HPA database.

Gene(ID):
CRABP2(1382)
Description:
This gene encodes a member of the retinoic acid (RA,a form of vitamin A) binding protein family and lipocalin,cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein,which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway,and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Sequence:
MPNFSGNWKIIRSENFEELLKVLGVNVMLRKIAVAAASKPAVEIKQEGDTFYIKTSTTVRTTEINFKVGEEFEEQTVDGRPCKSLVKWESENKMVCEQKLLKGEGPKTSWTRELTNDGELILTMTADDVVCTRVYVRE

Research Backgrounds

Function:

Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.

PTMs:

Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.

Subcellular Location:

Cytoplasm. Endoplasmic reticulum. Nucleus.
Note: Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Family&Domains:

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Restrictive clause

 

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