TSPO Recombinant Rabbit mAb - #BF3970

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Product: TSPO Recombinant Rabbit mAb
Catalog: BF3970
Description: Rabbit monoclonal antibody to TSPO
Application: WB IHC IF/ICC
Reactivity: Human, Mouse
Mol.Wt.: 19 kDa(Observed); 19kD(Calculated).
Uniprot: P30536

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit IgG
Application:
WB 1:2000-1:20000, IHC 1:100-1:1000, ICC
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human, Mouse
Clonality:
Monoclonal [ReFirm23417]
Specificity:
TSPO Recombinant Rabbit mAb detects endogenous levels of TSPO.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

DBI,IBP,MBR,PBR,PBS,BPBS,BZRP,PKBS,PTBR,mDRC,pk18

Immunogens

Immunogen:

A synthetic peptide from human TSPO

Uniprot:

P30536(TSPO_HUMAN) >>Visit HPA database.

Gene(ID):
TSPO(706)
Expression:
P30536 TSPO_HUMAN:

Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.

Description:
Present mainly in the mitochondrial compartment of peripheral tissues,the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported,one of the variants lacks an internal exon and is considered non-coding,and the other variants encode the same protein.
Sequence:
MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAMGYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE

Research Backgrounds

Function:

Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides.

Subcellular Location:

Mitochondrion membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.

Family&Domains:

Belongs to the TspO/BZRP family.

Research Fields

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

· Human Diseases > Infectious diseases: Viral > HTLV-I infection.

· Organismal Systems > Digestive system > Cholesterol metabolism.

Restrictive clause

 

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