RBM5 Antibody - #DF3206
| Product: | RBM5 Antibody |
| Catalog: | DF3206 |
| Description: | Rabbit polyclonal antibody to RBM5 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| Mol.Wt.: | 92KD,120kD; 92kD(Calculated). |
| Uniprot: | P52756 |
| RRID: | AB_2835586 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3206, RRID:AB_2835586.
Fold/Unfold
FLJ39876; G15; H37; LUCA 15; LUCA15; Protein G15; Putative tumor suppressor LUCA15; RBM 5; Rbm5; RBM5_HUMAN; Renal carcinoma antigen NY REN 9; Renal carcinoma antigen NY-REN-9; RMB 5; RMB5; RNA binding motif protein 5; RNA binding protein 5; RNA-binding motif protein 5; RNA-binding protein 5; Tumor suppressor LUCA15;
Immunogens
Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines.
- P52756 RBM5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGSDKRVSRTERSGRYGSIIDRDDRDERESRSRRRDSDYKRSSDDRRGDRYDDYRDYDSPERERERRNSDRSEDGYHSDGDYGEHDYRHDISDERESKTIMLRGLPITITESDIREMMESFEGPQPADVRLMKRKTGVSRGFAFVEFYHLQDATSWMEANQKKLVIQGKHIAMHYSNPRPKFEDWLCNKCCLNNFRKRLKCFRCGADKFDSEQEVPPGTTESVQSVDYYCDTIILRNIAPHTVVDSIMTALSPYASLAVNNIRLIKDKQTQQNRGFAFVQLSSAMDASQLLQILQSLHPPLKIDGKTIGVDFAKSARKDLVLSDGNRVSAFSVASTAIAAAQWSSTQSQSGEGGSVDYSYLQPGQDGYAQYAQYSQDYQQFYQQQAGGLESDASSASGTAVTTTSAAVVSQSPQLYNQTSNPPGSPTEEAQPSTSTSTQAPAASPTGVVPGTKYAVPDTSTYQYDESSGYYYDPTTGLYYDPNSQYYYNSLTQQYLYWDGEKETYVPAAESSSHQQSGLPPAKEGKEKKEKPKSKTAQQIAKDMERWAKSLNKQKENFKNSFQPVNSLREEERRESAAADAGFALFEKKGALAERQQLIPELVRNGDEENPLKRGLVAAYSGDSDNEEELVERLESEEEKLADWKKMACLLCRRQFPNKDALVRHQQLSDLHKQNMDIYRRSRLSEQELEALELREREMKYRDRAAERREKYGIPEPPEPKRKKQFDAGTVNYEQPTKDGIDHSNIGNKMLQAMGWREGSGLGRKCQGITAPIEAQVRLKGAGLGAKGSAYGLSGADSYKDAVRKAMFARFTEME
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P52756 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S8 | Phosphorylation | Uniprot | |
| T10 | Phosphorylation | Uniprot | |
| Y16 | Phosphorylation | Uniprot | |
| S18 | Phosphorylation | Uniprot | |
| S37 | Phosphorylation | Uniprot | |
| Y51 | Phosphorylation | Uniprot | |
| Y54 | Phosphorylation | Uniprot | |
| Y57 | Phosphorylation | Uniprot | |
| S59 | Phosphorylation | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| S72 | Phosphorylation | Uniprot | |
| Y76 | Phosphorylation | Uniprot | |
| S78 | Phosphorylation | Uniprot | |
| Y82 | Phosphorylation | Uniprot | |
| S112 | Phosphorylation | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| T242 | Phosphorylation | Uniprot | |
| T249 | Phosphorylation | Uniprot | |
| S252 | Phosphorylation | Uniprot | |
| Y254 | Phosphorylation | Uniprot | |
| S256 | Phosphorylation | Uniprot | |
| K306 | Ubiquitination | Uniprot | |
| K314 | Ubiquitination | Uniprot | |
| S444 | Phosphorylation | Uniprot | |
| K542 | Acetylation | Uniprot | |
| K549 | Acetylation | Uniprot | |
| K553 | Acetylation | Uniprot | |
| S576 | Phosphorylation | Uniprot | |
| Y620 | Phosphorylation | Uniprot | |
| S621 | Phosphorylation | Uniprot | |
| S624 | Phosphorylation | Uniprot | |
| S636 | Phosphorylation | Uniprot | |
| S669 | Phosphorylation | Uniprot | |
| Y712 | Phosphorylation | Uniprot | |
| K724 | Ubiquitination | Uniprot | |
| Y733 | Phosphorylation | Uniprot | |
| K765 | Sumoylation | Uniprot | |
| T770 | Phosphorylation | Uniprot | |
| R778 | Methylation | Uniprot | |
| K780 | Methylation | Uniprot | |
| K787 | Methylation | Uniprot | |
| S789 | Phosphorylation | Uniprot | |
| Y791 | Phosphorylation | Uniprot | |
| S794 | Phosphorylation | Uniprot | |
| K800 | Ubiquitination | Uniprot | |
| T812 | Phosphorylation | Uniprot |
Research Backgrounds
Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.
Nucleus.
Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines.
Component of the spliceosome A complex (also known as the prespliceosome). Appears to dissociate from the spliceosome upon formation of the spliceosome B complex (also known as the precatalytic spliceosome), in which the heterotrimeric U4/U6.U5 snRNPs are bound. Interacts with U2AF2; this interaction is direct. Also interacts with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200; these interactions may be indirect.
Belongs to the RBM5/RBM10 family.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.