Casein Kinase 2 beta Recombinant Rabbit mAb - #BF4185

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Product: Casein Kinase 2 beta Recombinant Rabbit mAb
Catalog: BF4185
Description: Rabbit monoclonal antibody to Casein Kinase 2 beta
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 25 kDa(Observed); 25kD(Calculated).
Uniprot: P67870

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit IgG
Application:
WB 1:1000, IHC 1:100-1:200, ICC
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human, Mouse, Rat
Clonality:
Monoclonal [ReFirm23632]
Specificity:
Casein Kinase 2 beta Recombinant Rabbit mAb detects endogenous levels of Casein Kinase 2 beta.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

G5A,CK2B,CK2N,Ckb1,Ckb2,CSK2B,POBINDS

Immunogens

Immunogen:

A synthetic peptide from human Casein Kinase 2 beta

Uniprot:

P67870(CSK2B_HUMAN) >>Visit HPA database.

Gene(ID):
CSNK2B(1460)
Description:
This gene encodes the beta subunit of casein kinase II,a ubiquitous protein kinase which regulates metabolic pathways,signal transduction,transcription,translation,and replication. The enzyme is composed of three subunits,alpha,alpha prime and beta,which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic,while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene.
Sequence:
MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDEELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPANQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR

Research Backgrounds

Function:

Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.

PTMs:

Phosphorylated by alpha subunit.

Family&Domains:

Belongs to the casein kinase 2 subunit beta family.

Research Fields

· Cellular Processes > Cellular community - eukaryotes > Adherens junction.   (View pathway)

· Environmental Information Processing > Signal transduction > NF-kappa B signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Wnt signaling pathway.   (View pathway)

· Genetic Information Processing > Translation > Ribosome biogenesis in eukaryotes.

· Human Diseases > Infectious diseases: Viral > Measles.

· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.

· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.

Restrictive clause

 

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For Research Use Only.
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