COPS2 Antibody - #DF3222
| Product: | COPS2 Antibody |
| Catalog: | DF3222 |
| Description: | Rabbit polyclonal antibody to COPS2 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 55 KD; 52kD(Calculated). |
| Uniprot: | P61201 |
| RRID: | AB_2835602 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3222, RRID:AB_2835602.
Fold/Unfold
ALIEN; Alien Drosophila himolog of; Alien homolog; COP 9; COP9; COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis); COP9 constitutive photomorphogenic homolog subunit 2; COP9 signalosome complex subunit 2; COPS 2; Cops2; CSN2; CSN2_HUMAN; JAB1 containing signalosome subunit 2; JAB1-containing signalosome subunit 2; SGN 2; SGN2; Signalosome subunit 2; Thyroid Hormone Receptor Interactor15; Thyroid Hormone Receptor Interactor 15; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP 15; TRIP-15; TRIP15;
Immunogens
- P61201 CSN2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYISTSKQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILRQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P61201 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K48 | Ubiquitination | Uniprot | |
| K56 | Ubiquitination | Uniprot | |
| K64 | Ubiquitination | Uniprot | |
| T97 | Phosphorylation | Uniprot | |
| S111 | Phosphorylation | Uniprot | |
| Y118 | Phosphorylation | Uniprot | |
| T121 | Phosphorylation | Uniprot | |
| K157 | Ubiquitination | Uniprot | |
| Y159 | Phosphorylation | Uniprot | |
| Y165 | Phosphorylation | Uniprot | |
| K225 | Ubiquitination | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| K263 | Ubiquitination | Uniprot | |
| Y279 | Phosphorylation | Uniprot | |
| K300 | Ubiquitination | Uniprot | |
| Y302 | Phosphorylation | Uniprot | |
| K331 | Ubiquitination | Uniprot | |
| R352 | Methylation | Uniprot | |
| K364 | Ubiquitination | Uniprot | |
| K415 | Ubiquitination | Uniprot | |
| K426 | Acetylation | Uniprot | |
| K426 | Ubiquitination | Uniprot | |
| K441 | Ubiquitination | Uniprot |
Research Backgrounds
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Phosphorylated by CK2 and PKD kinases.
Cytoplasm. Nucleus.
Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1. In the complex, it probably interacts directly with COPS1, COPS4, COPS5, COPS6 and COPS7 (COPS7A or COPS7B). Specifically interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction (By similarity). Interacts with CUL1 and CUL2. Interacts with IRF8/ICSBP1 and with nuclear receptors NR2F1 and NR0B1. Interacts with NIF3L1 (By similarity).
Belongs to the CSN2 family.
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