TLE2 Antibody - #DF3239
| Product: | TLE2 Antibody |
| Catalog: | DF3239 |
| Description: | Rabbit polyclonal antibody to TLE2 |
| Application: | WB IF/ICC |
| Reactivity: | Human |
| Mol.Wt.: | 110 KD; 80kD(Calculated). |
| Uniprot: | Q04725 |
| RRID: | AB_2835619 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3239, RRID:AB_2835619.
Fold/Unfold
enhancer of split groucho 2; enhancer of split groucho 2; Enhancer of split groucho-like protein 2; ESG; ESG2; FLJ41188; GRG2; Groucho2; KIAA4188; MGC124808; mKIAA4188; Tle2; Tle2 protein; TLE2_HUMAN; transducin like enhancer of split 2; Transducin like enhancer of split 2, homolog of Drosophila E(sp1); Transducin like enhancer protein 2; Transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); Transducin-like enhancer of split 2, homolog of Drosophila E(spl); Transducin-like enhancer protein 2;
Immunogens
A synthesized peptide derived from human TLE2, corresponding to a region within the internal amino acids.
- Q04725 TLE2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MYPQGRHPTPLQSGQPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNSLIGQQLQPLSHHAPPVPLTPRPAGLVGGSATGLLALSGALAAQAQLAAAVKEDRAGVEAEGSRVERAPSRSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPYESDEDKSDYNLVVDEDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSFSLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEVVY
Research Backgrounds
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
Ubiquitinated by XIAP/BIRC4.
Nucleus.
In all tissues examined, mostly in heart, brain, and muscle.
WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
Belongs to the WD repeat Groucho/TLE family.
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