MUC13 Recombinant Rabbit mAb - #BF4569

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Product: MUC13 Recombinant Rabbit mAb
Catalog: BF4569
Description: Rabbit monoclonal antibody to MUC13
Application: WB IHC IF/ICC
Reactivity: Human
Mol.Wt.: 70-175kD(Observed); 55kD(Calculated).
Uniprot: Q9H3R2

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit IgG
Application:
WB 1:1000, IHC 1:1000-1:5000, ICC
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Monoclonal [ReFirm24019]
Specificity:
MUC13 Recombinant Rabbit mAb detects endogenous levels of MUC13.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Down-regulated in colon cancer 1; DRCC1; FLJ20063; MUC 13; MUC-13; Muc13; MUC13 Down regulated in colon cancer 1; MUC13_HUMAN; Mucin 13, cell surface associated; Mucin-13; PRO20221; RECC; UNQ6194;

Immunogens

Immunogen:

A synthetic peptide from human MUC13

Uniprot:

Q9H3R2(MUC13_HUMAN) >>Visit HPA database.

Gene(ID):
MUC13(56667)
Expression:
Q9H3R2 MUC13_HUMAN:

Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach.

Description:
Epithelial mucins,such as MUC13,are a family of secreted and cell surface glycoproteins expressed by ductal and glandular epithelial tissues (Williams et al.,2001 ).
Sequence:
MKAIIHLTLLALLSVNTATNQGNSADAVTTTETATSGPTVAAADTTETNFPETASTTANTPSFPTATSPAPPIISTHSSSTIPTPAPPIISTHSSSTIPIPTAADSESTTNVNSLATSDIITASSPNDGLITMVPSETQSNNEMSPTTEDNQSSGPPTGTALLETSTLNSTGPSNPCQDDPCADNSLCVKLHNTSFCLCLEGYYYNSSTCKKGKVFPGKISVTVSETFDPEEKHSMAYQDLHSEITSLFKDVFGTSVYGQTVILTVSTSLSPRSEMRADDKFVNVTIVTILAETTSDNEKTVTEKINKAIRSSSSNFLNYDLTLRCDYYGCNQTADDCLNGLACDCKSDLQRPNPQSPFCVASSLKCPDACNAQHKQCLIKKSGGAPECACVPGYQEDANGNCQKCAFGYSGLDCKDKFQLILTIVGTIAGIVILSMIIALIVTARSNNKTKHIEEENLIDEDFQNLKLRSTGFTNLGAEGSVFPKVRITASRDSQMQNPYSRHSSMPRPDY

Research Backgrounds

Function:

Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.

PTMs:

Cleaved into two subunits, alpha and beta, probably between the first EGF domain and the SEA domain. Beta subunit contains the cytoplasmic tail and alpha subunit the extracellular tail. The homooligomerization into dimers is dependent on intrachain disulfide bonds.

Highly N-glycosylated.

Subcellular Location:

Cell membrane>Single-pass type I membrane protein. Apical cell membrane. Secreted.
Note: Also exists as a soluble form.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach.

Restrictive clause

 

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