PAI 2 Recombinant Rabbit mAb - #BF4585

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Product: PAI 2 Recombinant Rabbit mAb
Catalog: BF4585
Description: Rabbit monoclonal antibody to PAI 2
Application: WB
Reactivity: Human, Mouse, Rat
Mol.Wt.: 47 kDa(Observed); 47kD(Calculated).
Uniprot: P05120

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit IgG
Application:
WB 1:1000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human, Mouse, Rat
Clonality:
Monoclonal [ReFirm24035]
Specificity:
PAI 2 Recombinant Rabbit mAb detects endogenous levels of PAI 2.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

HsT1201; Monocyte Arg serpin; Monocyte Arg-serpin; Monocyte Arginine-serpin; Monocyte-derived plasminogen activator inhibitor; PAI; PAI-2; PAI2; PAI2_HUMAN; Placental plasminogen activator inhibitor; PLANH2; Plasminogen activator inhibitor 2; plasminogen activator inhibitor, type 2; plasminogen activator inhibitor, type II (arginine-serpin); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2; Serpin B2; serpin peptidase inhibitor, clade B (ovalbumin), member 2; Serpinb2; Urokinase inhibitor;

Immunogens

Immunogen:

A synthetic peptide from human PAI 2

Uniprot:

P05120(PAI2_HUMAN) >>Visit HPA database.

Gene(ID):
SERPINB2(5055)
Description:
Inhibits urokinase-type plasminogen activator
Sequence:
MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQFNEVGANAVTPMTPENFTSCGFMQQIQKGSYPDAILQAQAADKIHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGPQFVADHPFLFLIMHKITNCILFFGRFSSP

Research Backgrounds

Function:

Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.

PTMs:

The signal sequence is not cleaved.

Subcellular Location:

Cytoplasm. Secreted>Extracellular space.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Family&Domains:

Belongs to the serpin family. Ov-serpin subfamily.

Research Fields

· Organismal Systems > Immune system > Complement and coagulation cascades.   (View pathway)

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For Research Use Only.
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