Connexin 32 Recombinant Rabbit mAb - #BF4614

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Product: Connexin 32 Recombinant Rabbit mAb
Catalog: BF4614
Description: Rabbit monoclonal antibody to Connexin 32
Application: WB IHC
Reactivity: Human, Rat
Mol.Wt.: 32 kDa(Observed); 32kD(Calculated).
Uniprot: P08034

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Related Downloads
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit IgG
Application:
WB 1:1000-1:5000, IHC 1:100-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human, Rat
Clonality:
Monoclonal [ReFirm24064]
Specificity:
Connexin 32 Recombinant Rabbit mAb detects endogenous levels of Connexin 32.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Charcot Marie Tooth neuropathy X linked; CMTX 1; CMTX; CMTX1; Connexin-32; Connexin32; CX 32; Cx32; CXB1_HUMAN; GAP junction 28 kDa liver protein; Gap junction beta 1 protein; Gap junction beta-1 protein; Gap junction protein beta 1 32kD; Gap junction protein beta 1; GJB 1; GJB1;

Immunogens

Immunogen:

A synthetic peptide from human Connexin 32

Uniprot:

P08034(CXB1_HUMAN) >>Visit HPA database.

Gene(ID):
GJB1(2705)
Description:
This gene encodes a member of the gap junction protein family. The gap junction proteins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels,the gap junction proteins are divided into two categories,alpha and beta. Mutations in this gene cause X-linked Charcot-Marie-Tooth disease,an inherited peripheral neuropathy. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Sequence:
MNWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSSFICNTLQPGCNSVCYDQFFPISHVRLWSLQLILVSTPALLVAMHVAHQQHIEKKMLRLEGHGDPLHLEEVKRHKVHISGTLWWTYVISVVFRLLFEAVFMYVFYLLYPGYAMVRLVKCDVYPCPNTVDCFVSRPTEKTVFTVFMLAASGICIILNVAEVVYLIIRACARRAQRRSNPPSRKGSGFGHRLSPEYKQNEINKLLSEQDGSLKDILRRSPGTGAGLAEKSDRCSAC

Research Backgrounds

Function:

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Subcellular Location:

Cell membrane>Multi-pass membrane protein. Cell junction>Gap junction.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Family&Domains:

Belongs to the connexin family. Beta-type (group I) subfamily.

Restrictive clause

 

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For Research Use Only.
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