SYCP3 Recombinant Rabbit mAb - #BF4621

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Product: SYCP3 Recombinant Rabbit mAb
Catalog: BF4621
Description: Rabbit monoclonal antibody to SYCP3
Application: WB
Reactivity: Human, Mouse, Rat
Mol.Wt.: 28 kDa(Observed); 28kD(Calculated).
Uniprot: Q8IZU3

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Product Info

Source:
Rabbit IgG
Application:
WB 1:1000-1:5000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human, Mouse, Rat
Clonality:
Monoclonal [ReFirm24071]
Specificity:
SYCP3 Recombinant Rabbit mAb detects endogenous levels of SYCP3.
Conjugate:
Unconjugated.
Purification:
Affinity-chromatography.
Storage:
Rabbit IgG in Tris-Glycine (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

choline phosphotransferase 1; chpt1; COR 1; COR1; MGC71888; RNASCP3; SCP 3; SCP-3; SCP3; SPGF4; Sycp 3; Sycp3; SYCP3_HUMAN; Synaptonemal complex protein 3;

Immunogens

Immunogen:

A synthetic peptide from human SYCP3

Uniprot:

Q8IZU3(SYCP3_HUMAN) >>Visit HPA database.

Gene(ID):
SYCP3(50511)
Expression:
Q8IZU3 SYCP3_HUMAN:

Testis-specific.

Description:
This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis,recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein.
Sequence:
MVSSGKKYSRKSGKPSVEDQFTRAYDFETEDKKDLSGSEEDVIEGKTAVIEKRRKKRSSAGVVEDMGGEVQNMLEGVGVDINKALLAKRKRLEMYTKASLKTSNQKIEHVWKTQQDQRQKLNQEYSQQFLTLFQQWDLDMQKAEEQEEKILNMFRQQQKILQQSRIVQSQRLKTIKQLYEQFIKSMEELEKNHDNLLTGAQNEFKKEMAMLQKKIMMETQQQEIASVRKSLQSMLF

Research Backgrounds

Function:

Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity). Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity).

PTMs:

Phosphorylated.

Subcellular Location:

Nucleus. Chromosome. Chromosome>Centromere.
Note: It is present in early unpaired cores, in the lateral domains of the synaptonemal complex and in the chromosome cores when they separate at diplotene. It is found axial to the metaphase I chromosomes and in association with pairs of sister centromeres. The centromere-associated protein becomes dissociated from the centromeres at anaphase II and is not found in mitotic metaphase centromeres.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Testis-specific.

Family&Domains:

Composed of a long central coiled coil domain. The N-terminal and C-terminal regions interact with DNA.

Belongs to the XLR/SYCP3 family.

Research Fields

· Genetic Information Processing > Replication and repair > Homologous recombination.

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For Research Use Only.
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