CDK10 Antibody - #DF3285
| Product: | CDK10 Antibody |
| Catalog: | DF3285 |
| Description: | Rabbit polyclonal antibody to CDK10 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| Mol.Wt.: | 43 KD; 41kD(Calculated). |
| Uniprot: | Q15131 |
| RRID: | AB_2835653 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3285, RRID:AB_2835653.
Fold/Unfold
CDC2 related protein kinase; Cdk10; CDK10_HUMAN; Cell division protein kinase 10; Cyclin dependent kinase 10; Cyclin dependent kinase related protein; Cyclin-dependent kinase 10; PISSLRE; Serine/threonine protein kinase PISSLRE; Serine/threonine-protein kinase PISSLRE;
Immunogens
- Q15131 CDK10_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAEPDLECEQIRLKCIRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15131 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K41 | Ubiquitination | Uniprot | |
| T49 | Phosphorylation | Uniprot | |
| Y50 | Phosphorylation | Uniprot | |
| Y54 | Phosphorylation | Uniprot | |
| K68 | Ubiquitination | Uniprot | |
| K76 | Ubiquitination | Uniprot | |
| T133 | Phosphorylation | Uniprot | |
| K178 | Ubiquitination | Uniprot | |
| K193 | Ubiquitination | Uniprot | |
| T196 | Phosphorylation | Uniprot | |
| Y204 | Phosphorylation | Uniprot |
Research Backgrounds
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling.
Cytoplasm>Cytoskeleton>Cilium basal body.
Heterodimer with CCNQ, the interaction is required for kinase activity. Interacts with ETS2. Interacts with PRK2.
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Restrictive clause
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For Research Use Only.
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