TUSC5 Antibody - #DF3345

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Product: TUSC5 Antibody
Catalog: DF3345
Description: Rabbit polyclonal antibody to TUSC5
Application: WB IHC IF/ICC
Reactivity: Human, Rat
Mol.Wt.: 22 KD; 19kD(Calculated).
Uniprot: Q8IXB3
RRID: AB_2835712

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Rat
Clonality:
Polyclonal
Specificity:
TUSC5 Antibody detects endogenous levels of total TUSC5.
RRID:
AB_2835712
Cite Format: Affinity Biosciences Cat# DF3345, RRID:AB_2835712.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Dispanin subfamily B member 1; DSPB1; Interferon-induced transmembrane domain-containing protein D3; LOST1; Protein located at seventeen p thirteen point three 1; Protein located at seventeen-p-thirteen point three 1; Tumor suppressor candidate 5; Tusc5; TUSC5_HUMAN;

Immunogens

Immunogen:
Uniprot:

Q8IXB3(TARG1_HUMAN) >>Visit HPA database.

Gene(ID):
TUSC5(286753)
Expression:
Q8IXB3 TARG1_HUMAN:

Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus (PubMed:12660825). Expressed in adipose tissue (PubMed:26629404).

Sequence:
MAHPVQSEFPSAQEPGSAAFLDLPEMEILLTKAENKDDKTLNLSKTLSGPLDLEQNSQGLPFKAISEGHLEAPLPRSPSRASSRRASSIATTSYAQDQEAPRDYLILAVVACFCPVWPLNLIPLIISIMSRSSMQQGNVDGARRLGRLARLLSITLIIMGIVIIMVAVTVNFTVQKK

PTMs - Q8IXB3 As Substrate

Site PTM Type Enzyme
S11 Phosphorylation
S48 Phosphorylation
S57 Phosphorylation
S66 Phosphorylation
S77 Phosphorylation
S87 Phosphorylation
S88 Phosphorylation
T169 Phosphorylation

Research Backgrounds

Function:

Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation.

Subcellular Location:

Cell membrane>Multi-pass membrane protein. Endomembrane system>Multi-pass membrane protein. Cytoplasm>Perinuclear region.
Note: Shifts from low-density microsome vesicles to the cell membrane upon insulin stimulation.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus. Expressed in adipose tissue.

Subunit Structure:

Interacts with SLC2A4; the interaction is required for proper SLC2A4 reacycling after insulin stimulation.

Family&Domains:

Belongs to the CD225/Dispanin family.

Restrictive clause

 

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