Product: SMRC2 Antibody
Catalog: DF3363
Description: Rabbit polyclonal antibody to SMRC2
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog
Mol.Wt.: 160 KD; 133kD(Calculated).
Uniprot: Q8TAQ2
RRID: AB_2835721

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 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

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Product Info

WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Pig(100%), Bovine(92%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%)
SMRC2 Antibody detects endogenous levels of total SMRC2.
Cite Format: Affinity Biosciences Cat# DF3363, RRID:AB_2835721.
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.


BAF 170; BAF170; BRG1 associated factor 170; BRG1-associated factor 170; Chromatin remodeling complex BAF170 subunit; CRACC 2; CRACC2; Mammalian chromatin remodeling complex BRG1 associated factor 170; Rsc 8; Rsc8; SMARCC 2; Smarcc2; SMRC2_HUMAN; SWI/SNF complex 170 kDa subunit; SWI/SNF complex subunit SMARCC2; SWI/SNF related matrix associated actin dependent regulator of chromatin c2; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2; SWI3 like protein;



Ubiquitously expressed.




Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q8TAQ2 As Substrate

Site PTM Type Enzyme
K37 Ubiquitination
S69 Phosphorylation
S102 Phosphorylation
C145 S-Nitrosylation
K157 Ubiquitination
K161 Ubiquitination
S175 Phosphorylation
Y179 Phosphorylation
T230 Phosphorylation
K275 Ubiquitination
T276 Phosphorylation
S283 Phosphorylation
S286 Phosphorylation
Y296 Phosphorylation
S302 Phosphorylation
S304 Phosphorylation
S306 Phosphorylation
T308 Phosphorylation
S321 Phosphorylation
T322 Phosphorylation
Y324 Phosphorylation
K326 Acetylation
S327 Phosphorylation
S347 Phosphorylation
S367 Phosphorylation
S369 Phosphorylation
T376 Phosphorylation
T378 Phosphorylation
S387 Phosphorylation
T390 Phosphorylation
S399 Phosphorylation
T400 Phosphorylation
K453 Ubiquitination
K457 Ubiquitination
T548 Phosphorylation
S553 Phosphorylation
S555 Phosphorylation
K564 Ubiquitination
K566 Ubiquitination
K568 Ubiquitination
T579 Phosphorylation
Y582 Phosphorylation
T583 Phosphorylation
K622 Ubiquitination
C635 S-Nitrosylation
K694 Ubiquitination
S695 Phosphorylation
K702 Ubiquitination
K704 Sumoylation
K704 Ubiquitination
K724 Ubiquitination
T726 Phosphorylation
K728 Ubiquitination
S738 Phosphorylation
S754 Phosphorylation
K769 Acetylation
K795 Acetylation
S806 Phosphorylation
S810 Phosphorylation
S813 Phosphorylation
K836 Ubiquitination
S841 Phosphorylation
K872 Ubiquitination
K874 Ubiquitination
K885 Ubiquitination
S886 Phosphorylation
K897 Ubiquitination
K898 Ubiquitination
K902 Ubiquitination
R931 Methylation
K940 Ubiquitination
S969 Phosphorylation Q13315 (ATM) , Q13535 (ATR)

Research Backgrounds


Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity).

Subcellular Location:


Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Ubiquitously expressed.

Subunit Structure:

Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific (Probable). Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin. Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin. May also interact with the SIN3A histone deacetylase transcription repressor complex in conjunction with SMARCA2 and SMARCA4. Interacts with SMARD1. Interacts with KDM6B (By similarity). Interaction with RCOR1. Interacts with DPF2. Interacts with ERCC6.


Belongs to the SMARCC family.

Research Fields

· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma.   (View pathway)

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