Product: AVEN Antibody
Catalog: DF3519
Description: Rabbit polyclonal antibody to AVEN
Application: WB IHC IF/ICC
Reactivity: Human
Mol.Wt.: 55 KD; 39kD(Calculated).
Uniprot: Q9NQS1
RRID: AB_2835739

View similar products>>

   Size Price Inventory
 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

For pricing and ordering contact:
Local distributors

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
AVEN Antibody detects endogenous levels of total AVEN.
RRID:
AB_2835739
Cite Format: Affinity Biosciences Cat# DF3519, RRID:AB_2835739.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

1700013A01Rik; 1700056A21Rik; Apoptosis caspase activation inhibitor; AVEN; AVEN_HUMAN; Cell death regulator Aven; mAven L; mAven S; MGC124011; OTTMUSP00000016129; PDCD12; Programmed cell death 12; RP23-52C15.2;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Expression:
Q9NQS1 AVEN_HUMAN:

Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart, skeletal muscle, liver, kidney and pancreas.

Sequence:
MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPVEDDSDAETYGEENDEQGNYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDSEASCPKQNSAFYVDSELLVRALQELPLCLRLNVAAELVQGTVPLEVPQVKPKRTDDGKGLGMQLKGPLGPGGRGPIFELKSVAAGCPVLLGKDNPSPGPSRDSQKPTSPLQSAGDHLEEELDLLLNLDAPIKEGDNILPDQTSQDLKSKEDGEVVQEEEVCAKPSVTEEKNMEPEQPSTSKNVTEEELEDWLDSMIS

PTMs - Q9NQS1 As Substrate

Site PTM Type Enzyme
R17 Methylation
R28 Methylation
R37 Methylation
R50 Methylation
S94 Phosphorylation
T98 Phosphorylation
Y99 Phosphorylation
Y109 Phosphorylation
S116 Phosphorylation
Y121 Phosphorylation
S135 Phosphorylation Q13315 (ATM)
S151 Phosphorylation
K161 Ubiquitination
K215 Ubiquitination
K217 Ubiquitination
K230 Methylation
K230 Ubiquitination
R238 Methylation
K245 Methylation
K245 Ubiquitination
S261 Phosphorylation
S265 Phosphorylation
S268 Phosphorylation
S273 Phosphorylation
S308 Phosphorylation Q13315 (ATM)
C326 S-Nitrosylation
S330 Phosphorylation

Research Backgrounds

Function:

Protects against apoptosis mediated by Apaf-1.

Subcellular Location:

Endomembrane system>Peripheral membrane protein.
Note: Associated with intracellular membranes.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart, skeletal muscle, liver, kidney and pancreas.

Subunit Structure:

Binds Apaf-1, BCL-2 and BAD (Bcl-xl).

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.