ES8L1 Antibody - #DF3367

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Product: ES8L1 Antibody
Catalog: DF3367
Description: Rabbit polyclonal antibody to ES8L1
Application: WB IHC IF/ICC
Reactivity: Human, Mouse
Prediction: Pig, Bovine, Horse, Sheep, Dog
Mol.Wt.: 80 KD; 80kD(Calculated).
Uniprot: Q8TE68
RRID: AB_2835749

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Dog(100%)
Clonality:
Polyclonal
Specificity:
ES8L1 Antibody detects endogenous levels of total ES8L1.
RRID:
AB_2835749
Cite Format: Affinity Biosciences Cat# DF3367, RRID:AB_2835749.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

DRC3; Epidermal growth factor receptor kinase substrate 8 like protein 1; Epidermal growth factor receptor kinase substrate 8-like protein 1; Epidermal growth factor receptor pathway substrate 8 related protein 1; Epidermal growth factor receptor pathway substrate 8-related protein 1; EPS8 like 1; EPS8 like protein 1; EPS8-like protein 1; EPS8-related protein 1; EPS8L 1; Eps8l1; EPS8R1; ES8L1; ES8L1_HUMAN; FLJ20258; MGC23164; MGC4642; PP10566;

Immunogens

Immunogen:
Uniprot:

Q8TE68(ES8L1_HUMAN) >>Visit HPA database.

Gene(ID):
EPS8L1(54869)
Expression:
Q8TE68 ES8L1_HUMAN:

Detected in placenta.

Sequence:
MSTATGPEAAPKPSAKSIYEQRKRYSTVVMADVSQYPVNHLVTFCLGEDDGVHTVEDASRKLAVMDSQGRVWAQEMLLRVSPDHVTLLDPASKEELESYPLGAIVRCDAVMPPGRSRSLLLLVCQEPERAQPDVHFFQGLRLGAELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETPPLQRRPSVRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFASSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWEPPVTDPQSRAWEDPVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAGKWVLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTPYPGPRLHHSQSPARSLNSTPPPPPAPAPAPPPALARPRWDRPRWDSCDSLNGLDPSEKEKFSQMLIVNEELQARLAQGRSGPSRAVPGPRAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLLEDKEKVSELEAVMEKQKKKVEGEVEMEVI

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
64
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q8TE68 As Substrate

Site PTM Type Enzyme
Y19 Phosphorylation
K61 Ubiquitination
S116 Phosphorylation
S118 Phosphorylation
T173 Phosphorylation
S182 Phosphorylation
T187 Phosphorylation
S195 Phosphorylation
S201 Phosphorylation
T202 Phosphorylation
S239 Phosphorylation
T305 Phosphorylation
Y316 Phosphorylation
S328 Phosphorylation
S494 Phosphorylation
Y526 Phosphorylation
Y529 Phosphorylation
Y535 Phosphorylation
S543 Phosphorylation
S545 Phosphorylation
S549 Phosphorylation
S552 Phosphorylation
T553 Phosphorylation
S580 Phosphorylation
S583 Phosphorylation
S617 Phosphorylation
S631 Phosphorylation
S634 Phosphorylation
T660 Phosphorylation
S676 Phosphorylation
Y684 Phosphorylation
S685 Phosphorylation
T688 Phosphorylation
K709 Acetylation
K712 Acetylation

Research Backgrounds

Function:

Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.

Subcellular Location:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Detected in placenta.

Subunit Structure:

Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin.

Family&Domains:

Belongs to the EPS8 family.

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