ORCTL-2 Antibody - #DF3394

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Product: ORCTL-2 Antibody
Catalog: DF3394
Description: Rabbit polyclonal antibody to ORCTL-2
Application: WB IHC IF/ICC
Reactivity: Human
Mol.Wt.: 43 KD; 45kD(Calculated).
Uniprot: Q96BI1
RRID: AB_2835776

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
ORCTL-2 Antibody detects endogenous levels of total ORCTL-2.
RRID:
AB_2835776
Cite Format: Affinity Biosciences Cat# DF3394, RRID:AB_2835776.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Beckwith Wiedemann syndrome chromosomal region 1 candidate gene A protein; Beckwith Wiedemann syndrome chromosome region 1 candidate A; BWR1A; BWSCR1A; DKFZp667A184; Efflux transporter like protein; HET; Imprinted multi membrane spanning polyspecific transporter related protein 1; IMPT1; ITM; MGC94186; ORCTL 2; ORCTL2; Organic cation transporter like protein 2; OTTMUSP00000030799; OTTMUSP00000030800; p45 Beckwith Wiedemann region 1 A; p45 BWR1A; SLC22A18; SLC22A1L; Solute carrier family 22 member 1 like; TSSC5; TSSC5v; Tumor suppressing STF cDNA 5 protein; Tumor suppressing subchromosomal transferable fragment candidate gene 5 protein;

Immunogens

Immunogen:
Uniprot:

Q96BI1(S22AI_HUMAN) >>Visit HPA database.

Gene(ID):
SLC22A18(5002)
Expression:
Q96BI1 S22AI_HUMAN:

Expressed at high levels in adult and fetal kidney and liver, and adult colon. Expressed in fetal renal proximal tubules (at protein level). Expressed at lower levels in heart, brain and lung.

Sequence:
MQGARAPRDQGRSPGRMSALGRSSVILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAASSPALPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWRKPMPQRKDKVR

PTMs - Q96BI1 As Substrate

Site PTM Type Enzyme
K210 Ubiquitination
S224 Phosphorylation
K229 Ubiquitination

Research Backgrounds

Function:

May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.

Subcellular Location:

Apical cell membrane>Multi-pass membrane protein.
Note: Localized at the apical membrane surface of renal proximal tubules.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed at high levels in adult and fetal kidney and liver, and adult colon. Expressed in fetal renal proximal tubules (at protein level). Expressed at lower levels in heart, brain and lung.

Subunit Structure:

Interacts with RNF167.

Family&Domains:

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

Restrictive clause

 

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