AHSA1 Antibody - #DF3513
| Product: | AHSA1 Antibody |
| Catalog: | DF3513 |
| Description: | Rabbit polyclonal antibody to AHSA1 |
| Application: | WB IF/ICC |
| Reactivity: | Human |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 38 KD; 38kD(Calculated). |
| Uniprot: | O95433 |
| RRID: | AB_2835875 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3513, RRID:AB_2835875.
Fold/Unfold
Activator of 90 kDa heat shock protein ATPase homolog 1; Activator of heat shock 90kDa protein ATPase homolog 1; AHA 1; AHA1; AHSA 1; Ahsa1; AHSA1_HUMAN; C14orf3; HSPC322; p38;
Immunogens
Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.
- O95433 AHSA1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAKWGEGDPRWIVEERADATNVNNWHWTERDASNWSTDKLKTLFLAVQVQNEEGKCEVTEVSKLDGEASINNRKGKLIFFYEWSVKLNWTGTSKSGVQYKGHVEIPNLSDENSVDEVEISVSLAKDEPDTNLVALMKEEGVKLLREAMGIYISTLKTEFTQGMILPTMNGESVDPVGQPALKTEERKAKPAPSKTQARPVGVKIPTCKITLKETFLTSPEELYRVFTTQELVQAFTHAPATLEADRGGKFHMVDGNVSGEFTDLVPEKHIVMKWRFKSWPEGHFATITLTFIDKNGETELCMEGRGIPAPEEERTRQGWQRYYFEGIKQTFGYGARLF
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O95433 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K3 | Acetylation | Uniprot | |
| K3 | Methylation | Uniprot | |
| K3 | Ubiquitination | Uniprot | |
| R30 | Methylation | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| K94 | Ubiquitination | Uniprot | |
| K137 | Ubiquitination | Uniprot | |
| Y151 | Phosphorylation | Uniprot | |
| K182 | Sumoylation | Uniprot | |
| T183 | Phosphorylation | Uniprot | |
| S193 | Phosphorylation | Uniprot | |
| K194 | Ubiquitination | Uniprot | |
| K203 | Acetylation | Uniprot | |
| K203 | Ubiquitination | Uniprot | |
| C207 | S-Nitrosylation | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| K212 | Acetylation | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| T214 | Phosphorylation | Uniprot | |
| T217 | Phosphorylation | Uniprot | |
| S218 | Phosphorylation | Uniprot | |
| Y223 | Phosphorylation | P00519 (ABL1) | Uniprot |
| T241 | Phosphorylation | Uniprot | |
| K249 | Acetylation | Uniprot | |
| K249 | Ubiquitination | Uniprot | |
| S258 | Phosphorylation | Uniprot | |
| K268 | Ubiquitination | Uniprot | |
| R305 | Methylation | Uniprot | |
| R321 | Methylation | Uniprot | |
| K328 | Ubiquitination | Uniprot | |
| Y333 | Phosphorylation | Uniprot | |
| R336 | Methylation | Uniprot |
Research Backgrounds
Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins.
Phosphorylation at Tyr-223 enhances binding to chaperone HSP90AA1.
Cytoplasm>Cytosol. Endoplasmic reticulum.
Note: May transiently interact with the endoplasmic reticulum.
Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.
Interacts with HSPCA/HSP90. Interacts (phosphorylated on Tyr-223) with HSP90AA1; the interaction activates HSP90AA1 ATPase activity. Interacts with HSP90AB1 (By similarity). Interacts with GCH1. Interacts with SRPK1. Interacts with FLCN.
(Microbial infection) Interacts with vesicular stomatitis virus glycoprotein (VSV G) (via cytoplasmic tail).
Belongs to the AHA1 family.
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