Product: ALS2CR4 Antibody
Catalog: DF3774
Description: Rabbit polyclonal antibody to ALS2CR4
Application: WB IF/ICC
Reactivity: Human, Mouse
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Mol.Wt.: 48 KD; 46kD(Calculated).
Uniprot: Q96Q45
RRID: AB_2835899

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Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(100%)
Clonality:
Polyclonal
Specificity:
ALS2CR4 Antibody detects endogenous levels of total ALS2CR4.
RRID:
AB_2835899
Cite Format: Affinity Biosciences Cat# DF3774, RRID:AB_2835899.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

ALS2CR4 protein, N terminus truncated; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Sequence:
MRTDSGARLEEGHLRPPRALPPVPSQDDIPLSRPKKKKPRTKNTPASASLEGLAQTAGRRPSEGNEPSTKELKEHPEAPVQRRQKKTRLPLELETSSTQKKSSSSSLLRNENGIDAEPAEEAVIQKPRRKTKKTQPAELQYANELGVEDEDIITDEQTTVEQQSVFTAPTGISQPVGKVFVEKSRRFQAADRSELIKTTENIDVSMDVKPSWTTRDVALTVHRAFRMIGLFSHGFLAGCAVWNIVVIYVLAGDQLSNLSNLLQQYKTLAYPFQSLLYLLLALSTISAFDRIDFAKISVAIRNFLALDPTALASFLYFTALILSLSQQMTSDRIHLYTPSSVNGSLWEAGIEEQILQPWIVVNLVVALLVGLSWLFLSYRPGMDLSEELMFSSEVEEYPDKEKEIKASS

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Chicken
100
Rabbit
100
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q96Q45 As Substrate

Site PTM Type Enzyme
S25 Phosphorylation
T41 Phosphorylation
K42 Ubiquitination
T44 Phosphorylation
S47 Phosphorylation
S49 Phosphorylation
T56 Phosphorylation
S62 Phosphorylation
S68 Phosphorylation
K70 Ubiquitination
K73 Ubiquitination
S97 Phosphorylation
K100 Ubiquitination
K101 Ubiquitination
S102 Phosphorylation
S103 Phosphorylation
S104 Phosphorylation
S105 Phosphorylation
S106 Phosphorylation
K126 Ubiquitination
T131 Phosphorylation
K183 Ubiquitination
K209 Ubiquitination

Research Backgrounds

Function:

Component of the transition zone in primary cilia. Required for ciliogenesis.

Subcellular Location:

Membrane>Multi-pass membrane protein. Cell projection>Cilium.
Note: Localizes at the proximal region of primary cilia were observed, consistent with localization to the transition zone. Anchored to the transition zone by RPGRIP1L.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Part of the tectonic-like complex (also named B9 complex). Interacts with TMEM107.

Family&Domains:

Belongs to the TMEM237 family.

Restrictive clause

 

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For Research Use Only.
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