Product: Cytochrome P450 4Z1 Antibody
Catalog: DF3590
Description: Rabbit polyclonal antibody to Cytochrome P450 4Z1
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 59 KD; 59kD(Calculated).
Uniprot: Q86W10
RRID: AB_2835962

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 100ul $280 In stock
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Product Info

IHC 1:50-1:200, IF/ICC 1:100-1:500, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Cytochrome P450 4Z1 Antibody detects endogenous levels of total Cytochrome P450 4Z1.
Cite Format: Affinity Biosciences Cat# DF3590, RRID:AB_2835962.
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.


CP4Z1_HUMAN; CYP4A20; CYP4Z1; CYPIVZ1; Cytochrome P450 4Z1; Cytochrome P450 family 4 subfamily Z polypeptide 1;



Preferentially detected in breast carcinoma tissue and mammary gland, whereas only marginal expression is found in all other tested tissues.


PTMs - Q86W10 As Substrate

Site PTM Type Enzyme
Y55 Phosphorylation
T154 Phosphorylation
Y376 Phosphorylation
K492 Ubiquitination

Research Backgrounds

Subcellular Location:

Endoplasmic reticulum membrane>Single-pass type II membrane protein. Microsome membrane>Single-pass type II membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Preferentially detected in breast carcinoma tissue and mammary gland, whereas only marginal expression is found in all other tested tissues.


Belongs to the cytochrome P450 family.


1). Plasma membrane localization of CYP4Z1 and CYP19A1 and the detection of anti-CYP19A1 autoantibodies in humans. International Immunopharmacology, 2019 (PubMed: 31082724) [IF=5.6]

Application: IF/ICC    Species: human    Sample: MCF-7 or MCF-10A cells

Fig. 2.| Detection of CYP4Z1 on the outer surface of non-permeabilized MCF-7 or MCF-10A cells by rabbit anti-CYP4Z1 IgG and goat anti-rabbit IgG conjugated to Alexa fluor 488. The non-permeabilized cells were probed with antibodies and stained with DAPI and Deep Red plasma membrane stain as indicated. Magnification is×1,000 for all images

2). Concomitant occurence of multiple autoantibodies against human cytochromes P450. International Immunopharmacology, 2021 (PubMed: 34464888) [IF=5.6]

3). Involvement of WNT2 in trophoblast cell behavior in preeclampsia development. CELL CYCLE, 2020 (PubMed: 32779546) [IF=4.3]

4). Upregulation of estrogen receptor alpha (ERα) expression in transgenic mice expressing human CYP4Z1. Breast Cancer Research and Treatment, 2021 (PubMed: 34725776) [IF=3.8]

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