ABHD2 Antibody - #DF3719
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3719, RRID:AB_2836083.
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2210009N18Rik; abhydrolase domain containing 2; Abhydrolase domain-containing protein 2; alpha/beta hydrolase domain containing protein 2; HS1 2; Labh 2; LABH2; Lung alpha/beta hydrolase 2; MGC107122; MGC111112; MGC26249; PHPS1 2; protein PHPS1-2;
Immunogens
- P08910 ABHD2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVGDDITMVICPGIANHSEKQYIRTFVDYAQKNGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYANAICQWERNKLQCSDTEQVEADLE
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P08910 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y27 | Phosphorylation | Uniprot | |
| K36 | Ubiquitination | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| S52 | Phosphorylation | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| T63 | Phosphorylation | Uniprot | |
| K64 | Ubiquitination | Uniprot | |
| K74 | Ubiquitination | Uniprot | |
| Y83 | Phosphorylation | Uniprot | |
| K85 | Ubiquitination | Uniprot | |
| K152 | Ubiquitination | Uniprot | |
| K266 | Ubiquitination | Uniprot | |
| K281 | Ubiquitination | Uniprot | |
| K282 | Ubiquitination | Uniprot | |
| K310 | Ubiquitination | Uniprot | |
| Y334 | Phosphorylation | Uniprot | |
| K411 | Ubiquitination | Uniprot | |
| S415 | Phosphorylation | Uniprot |
Research Backgrounds
Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation. May also play a role in smooth muscle cells migration (By similarity).
Cell projection>Cilium>Flagellum membrane>Single-pass type II membrane protein. Cell membrane>Single-pass type II membrane protein.
Present in sperm (at protein level).
Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
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