APBA3 Antibody - #DF3768
| Product: | APBA3 Antibody |
| Catalog: | DF3768 |
| Description: | Rabbit polyclonal antibody to APBA3 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Rat |
| Mol.Wt.: | 61 KD; 61kD(Calculated). |
| Uniprot: | O96018 |
| RRID: | AB_2836132 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3768, RRID:AB_2836132.
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Adapter protein X11gamma; amyloid beta (A4) precursor protein binding, family A, member 3; Amyloid beta A4 precursor protein-binding family A member 3; Amyloid beta precursor protein binding, family A, member 3 phosphotyrosine binding/ interacting domain (PTB) bearing protein; APBA3; APBA3_HUMAN; lin 10; MGC:15815; Mint 3; Mint-3; Neuron specific X11L2 protein; Neuron-specific X11L2 protein; Neuronal Munc18 1 interacting protein 3; Neuronal Munc18-1-interacting protein 3; phosphotyrosine binding/interacting domain (PTB) bearing protein; X11 like 2 protein 2; X11gamma; X11L2;
Immunogens
A synthesized peptide derived from human APBA3, corresponding to a region within N-terminal amino acids.
- O96018 APBA3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDFPTISRSPSGPPAMDLEGPRDILVPSEDLTPDSQWDPMPGGPGSLSRMELDESSLQELVQQFEALPGDLVGPSPGGAPCPLHIATGHGLASQEIADAHGLLSAEAGRDDLLGLLHCEECPPSQTGPEEPLEPAPRLLQPPEDPDEDSDSPEWVEGASAEQEGSRSSSSSPEPWLETVPLVTPEEPPAGAQSPETLASYPAPQEVPGPCDHEDLLDGVIFGARYLGSTQLVSERNPPTSTRMAQAREAMDRVKAPDGETQPMTEVDLFVSTKRIKVLTADSQEAMMDHALHTISYTADIGCVLVLMARRRLARRPAPQDHGRRLYKMLCHVFYAEDAQLIAQAIGQAFAAAYSQFLRESGIDPSQVGVHPSPGACHLHNGDLDHFSNSDNCREVHLEKRRGEGLGVALVESGWGSLLPTAVIANLLHGGPAERSGALSIGDRLTAINGTSLVGLPLAACQAAVRETKSQTSVTLSIVHCPPVTTAIIHRPHAREQLGFCVEDGIICSLLRGGIAERGGIRVGHRIIEINGQSVVATPHARIIELLTEAYGEVHIKTMPAATYRLLTGQEQPVYL
PTMs - O96018 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| T5 | Phosphorylation | P42345 (MTOR) | Uniprot |
| S7 | Phosphorylation | P42345 (MTOR) | Uniprot |
| S9 | Phosphorylation | Uniprot | |
| S11 | Phosphorylation | Uniprot | |
| S28 | Phosphorylation | Uniprot | |
| S46 | Phosphorylation | Uniprot | |
| Y225 | Phosphorylation | Uniprot | |
| T229 | Phosphorylation | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| S372 | Phosphorylation | Uniprot | |
| R517 | Methylation | Uniprot |
Research Backgrounds
May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.
Cytoplasm>Perinuclear region.
Expressed in all tissues examined with lower levels in brain and testis.
Binds to the cytoplasmic domain of amyloid protein (APP) in vivo. Interacts with HIF1AN (via N-terminus). Interacts with NECAB3; seems to mediate the interaction between NECAB3 and HIF1AN.
Composed of an N-terminal domain, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.
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