EPB41L2 Antibody - #DF3826

(2)  
Product: EPB41L2 Antibody
Catalog: DF3826
Description: Rabbit polyclonal antibody to EPB41L2
Application: WB IHC IF/ICC
Reactivity: Human
Mol.Wt.: 112 KD; 113kD(Calculated).
Uniprot: O43491
RRID: AB_2836183

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
EPB41L2 Antibody detects endogenous levels of total EPB41L2.
RRID:
AB_2836183
Cite Format: Affinity Biosciences Cat# DF3826, RRID:AB_2836183.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

4.1 G; 4.1G; AW555191; Band 4.1 like protein 2; Band 4.1-like protein 2; D10Ertd398e; DKFZp781D1972; DKFZp781H1755; E41L2_HUMAN; Epb41l2; Erythrocyte membrane protein band 4.1 like 2; Erythrocyte membrane protein band 4.1 like protein 2; Generally expressed protein 4.1; NBL2; OTTHUMP00000017197; OTTHUMP00000040262;

Immunogens

Immunogen:
Uniprot:

O43491(E41L2_HUMAN) >>Visit HPA database.

Gene(ID):
EPB41L2(2037)
Expression:
O43491 E41L2_HUMAN:

Widely expressed.

Sequence:
MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLRRQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPTKAPHLQLIEGKKNSLRVEGDNIYVRHSNLMLEELDKAQEDILKHQASISELKRNFMESTPEPRPNEWEKRRITPLSLQTQGSSHETLNIVEEKKRAEVGKDERVITEEMNGKEISPGSGPGEIRKVEPVTQKDSTSLSSESSSSSSESEEEDVGEYRPHHRVTEGTIREEQEYEEEVEEEPRPAAKVVEREEAVPEASPVTQAGASVITVETVIQENVGAQKIPGEKSVHEGALKQDMGEEAEEEPQKVNGEVSHVDIDVLPQIICCSEPPVVKTEMVTISDASQRTEISTKEVPIVQTETKTITYESPQIDGGAGGDSGTLLTAQTITSESVSTTTTTHITKTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEEGED

PTMs - O43491 As Substrate

Site PTM Type Enzyme
T2 Acetylation
T2 Phosphorylation
S7 Phosphorylation
K12 Ubiquitination
K13 Ubiquitination
S15 Phosphorylation
S16 Phosphorylation
T20 Phosphorylation
T23 Phosphorylation
K24 Ubiquitination
K28 Ubiquitination
S38 Phosphorylation
S39 Phosphorylation
K45 Ubiquitination
S47 Phosphorylation
S55 Phosphorylation
S57 Phosphorylation
S58 Phosphorylation
R72 Methylation
K83 Methylation
K83 Ubiquitination
K84 Ubiquitination
K86 Ubiquitination
S87 Phosphorylation
Y88 Phosphorylation
T89 Phosphorylation
K94 Acetylation
K99 Acetylation
K99 Ubiquitination
K100 Ubiquitination
T103 Phosphorylation
K114 Ubiquitination
K126 Ubiquitination
K135 Ubiquitination
K140 Ubiquitination
K144 Ubiquitination
S151 Phosphorylation
S157 Phosphorylation
S159 Phosphorylation
K160 Ubiquitination
S170 Phosphorylation
K171 Acetylation
K171 Ubiquitination
K176 Acetylation
K178 Ubiquitination
T180 Phosphorylation
K184 Acetylation
K184 Ubiquitination
K191 Acetylation
T194 Phosphorylation
K195 Ubiquitination
K203 Ubiquitination
K206 Ubiquitination
S208 Phosphorylation
K221 Ubiquitination
K239 Ubiquitination
K246 Ubiquitination
S266 Phosphorylation
K270 Ubiquitination
K369 Ubiquitination
K374 Ubiquitination
K380 Ubiquitination
S386 Phosphorylation
K399 Ubiquitination
S402 Phosphorylation
K444 Ubiquitination
K474 Ubiquitination
S499 Phosphorylation
K505 Ubiquitination
K507 Ubiquitination
T510 Phosphorylation
S513 Phosphorylation
K514 Acetylation
K514 Ubiquitination
Y517 Phosphorylation
S518 Phosphorylation
S529 Phosphorylation
R534 Methylation
S548 Phosphorylation
S550 Phosphorylation
S562 Phosphorylation
S575 Phosphorylation
Y577 Phosphorylation
S598 Phosphorylation
T600 Phosphorylation
K601 Ubiquitination
K611 Ubiquitination
S614 Phosphorylation
Y623 Phosphorylation
S627 Phosphorylation
K643 Methylation
K643 Ubiquitination
S647 Phosphorylation
S649 Phosphorylation
K652 Methylation
K652 Ubiquitination
S658 Phosphorylation
T659 Phosphorylation
K669 Acetylation
T673 Phosphorylation
S676 Phosphorylation
T679 Phosphorylation
S682 Phosphorylation
S683 Phosphorylation
T686 Phosphorylation
K693 Ubiquitination
K694 Acetylation
T706 Phosphorylation
K712 Ubiquitination
S715 Phosphorylation
S718 Phosphorylation
S734 Phosphorylation
S742 Phosphorylation
S743 Phosphorylation
S744 Phosphorylation
S748 Phosphorylation
Y756 Phosphorylation
T763 Phosphorylation
T766 Phosphorylation
R768 Methylation
Y773 Phosphorylation
S798 Phosphorylation
T801 Phosphorylation
S806 Phosphorylation
K827 Ubiquitination
S828 Phosphorylation
T875 Phosphorylation
S881 Phosphorylation
S884 Phosphorylation
K892 Ubiquitination
T905 Phosphorylation
Y906 Phosphorylation
S908 Phosphorylation
T944 Phosphorylation
K946 Ubiquitination
S950 Phosphorylation
S987 Phosphorylation
K995 Ubiquitination

Research Backgrounds

Function:

Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.

Subcellular Location:

Cytoplasm>Cytoskeleton. Cytoplasm>Cell cortex. Cell membrane.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Widely expressed.

Subunit Structure:

Interacts with FCGR1A. Interacts with TRPC4. Interacts (via CTD domain) with FKBP2 (By similarity). Interacts with NUMA1; this interaction is negatively regulated by CDK1 during metaphase and promotes anaphase-specific localization of NUMA1 in symmetrically dividing cells.

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