CAPN10 Antibody - #DF3866
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3866, RRID:AB_2836223.
Fold/Unfold
Calcium activated neutral protease; Calcium activated neutral proteinase 10; Calcium-activated neutral proteinase 10; calpain like protease CAPN10; Calpain-10; Calpain10; CAN10_HUMAN; CANP 10; CANP10; CAPN 10; CAPN10; EC 3.4.22.; KIAA1845; NIDDM1;
Immunogens
- Q9HC96 CAN10_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRAGRGATPARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARELGEFHAFIVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRNNSGFPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAVGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPGEFLLRVFSTGRVSLSAIRAVAKNTTPGAALPAGEWGTVQLRGSWRVGQTAGGSRNFASYPTNPCFPFSVPEGPGPRCVRITLHQHCRPSDTEFHPIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTIATRIDRPSIHSQEMLGQFLQEVSIMAVMKT
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9HC96 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K188 | Ubiquitination | Uniprot | |
| K348 | Ubiquitination | Uniprot | |
| S351 | Phosphorylation | Uniprot | |
| S359 | Phosphorylation | Uniprot | |
| Y465 | Phosphorylation | Uniprot | |
| Y466 | Phosphorylation | Uniprot | |
| K501 | Ubiquitination | Uniprot |
Research Backgrounds
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.
Detected in primary skeletal muscle cells (at protein level). Ubiquitous.
Belongs to the peptidase C2 family.
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