CRABP2 Antibody - #DF3914
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3914, RRID:AB_2836267.
Fold/Unfold
Cellular retinoic acid binding protein 2; Cellular retinoic acid binding protein II; Cellular retinoic acid-binding protein 2; Cellular retinoic acid-binding protein II; CRABP II; CRABP-II; Crabp2; CRABPII; RABP2_HUMAN; RBP6; Rretinoic acid-binding protein, cellular, type II;
Immunogens
- P29373 RABP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPNFSGNWKIIRSENFEELLKVLGVNVMLRKIAVAAASKPAVEIKQEGDTFYIKTSTTVRTTEINFKVGEEFEEQTVDGRPCKSLVKWESENKMVCEQKLLKGEGPKTSWTRELTNDGELILTMTADDVVCTRVYVRE
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P29373 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S13 | Phosphorylation | Uniprot | |
| K21 | Ubiquitination | Uniprot | |
| K31 | Ubiquitination | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| K45 | Sumoylation | Uniprot | |
| K45 | Ubiquitination | Uniprot | |
| T62 | Phosphorylation | Uniprot | |
| K83 | Ubiquitination | Uniprot | |
| K87 | Acetylation | Uniprot | |
| K87 | Sumoylation | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| S90 | Phosphorylation | Uniprot | |
| K99 | Ubiquitination | Uniprot | |
| K102 | Sumoylation | Uniprot | |
| K102 | Ubiquitination | Uniprot |
Research Backgrounds
Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.
Cytoplasm. Endoplasmic reticulum. Nucleus.
Note: Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
Interacts with RXR and RARA (By similarity). Interacts with importin alpha.
Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
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