CLCC1 Antibody - #DF3930
| Product: | CLCC1 Antibody |
| Catalog: | DF3930 |
| Description: | Rabbit polyclonal antibody to CLCC1 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Rat |
| Prediction: | Bovine, Horse, Sheep |
| Mol.Wt.: | 62 KD; 62kD(Calculated). |
| Uniprot: | Q96S66 |
| RRID: | AB_2836283 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3930, RRID:AB_2836283.
Fold/Unfold
Chloride channel CLIC like protein 1; KIAA0761; MCLC; Mid 1 related chloride channel 1; Mid 1 related chloride channel protein 1; OTTMUSP00000007700; OTTMUSP00000007701; RP23-217I18.1;
Immunogens
Expressed in the retina of the eye, with extensive expression in the lamina cribrosa, optic nerve, ganglion cell layer, inner nuclear layer, outer nuclear layer and retinal pigment epithelium.
- Q96S66 CLCC1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLCSLLLCECLLLVAGYAHDDDWIDPTDMLNYDAASGTMRKSQAKYGISGEKDVSPDLSCADEISECYHKLDSLTYKIDECEKKKREDYESQSNPVFRRYLNKILIEAGKLGLPDENKGDMHYDAEIILKRETLLEIQKFLNGEDWKPGALDDALSDILINFKFHDFETWKWRFEDSFGVDPYNVLMVLLCLLCIVVLVATELWTYVRWYTQLRRVLIISFLFSLGWNWMYLYKLAFAQHQAEVAKMEPLNNVCAKKMDWTGSIWEWFRSSWTYKDDPCQKYYELLLVNPIWLVPPTKALAVTFTTFVTEPLKHIGKGTGEFIKALMKEIPALLHLPVLIIMALAILSFCYGAGKSVHVLRHIGGPESEPPQALRPRDRRRQEEIDYRPDGGAGDADFHYRGQMGPTEQGPYAKTYEGRREILRERDVDLRFQTGNKSPEVLRAFDVPDAEAREHPTVVPSHKSPVLDTKPKETGGILGEGTPKESSTESSQSAKPVSGQDTSGNTEGSPAAEKAQLKSEAAGSPDQGSTYSPARGVAGPRGQDPVSSPCG
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96S66 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S42 | Phosphorylation | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| K70 | Ubiquitination | Uniprot | |
| Y76 | Phosphorylation | Uniprot | |
| K77 | Ubiquitination | Uniprot | |
| K85 | Ubiquitination | Uniprot | |
| Y89 | Phosphorylation | Uniprot | |
| K110 | Ubiquitination | Uniprot | |
| K275 | Ubiquitination | Uniprot | |
| K317 | Ubiquitination | Uniprot | |
| K324 | Acetylation | Uniprot | |
| Y351 | Phosphorylation | Uniprot | |
| T407 | O-Glycosylation | Uniprot | |
| Y412 | Phosphorylation | Uniprot | |
| K414 | Ubiquitination | Uniprot | |
| T434 | Phosphorylation | Uniprot | |
| K437 | Ubiquitination | Uniprot | |
| S438 | Phosphorylation | Uniprot | |
| R443 | Methylation | Uniprot | |
| T457 | Phosphorylation | Uniprot | |
| S461 | Phosphorylation | Uniprot | |
| K463 | Ubiquitination | Uniprot | |
| S464 | Phosphorylation | Uniprot | |
| T469 | O-Glycosylation | Uniprot | |
| K470 | Ubiquitination | Uniprot | |
| T474 | O-Glycosylation | Uniprot | |
| T482 | Phosphorylation | Uniprot | |
| S503 | Phosphorylation | Uniprot | |
| T506 | Phosphorylation | Uniprot | |
| S509 | Phosphorylation | Uniprot | |
| K518 | Ubiquitination | Uniprot | |
| S519 | Phosphorylation | Uniprot | |
| S524 | Phosphorylation | Uniprot | |
| S529 | Phosphorylation | Uniprot | |
| Y531 | Phosphorylation | Uniprot | |
| S532 | Phosphorylation | Uniprot | |
| S547 | Phosphorylation | Uniprot | |
| S548 | Phosphorylation | Uniprot | |
| C550 | S-Nitrosylation | Uniprot |
Research Backgrounds
Seems to act as a chloride ion channel. Plays a role in retina development.
Endoplasmic reticulum membrane>Multi-pass membrane protein. Golgi apparatus membrane>Multi-pass membrane protein. Nucleus membrane>Multi-pass membrane protein.
Note: Within the endoplasmic reticulum (ER), localizes to the mitochondria-associated ER membrane, a zone of contact between the ER and mitochondrial membranes.
Expressed in the retina of the eye, with extensive expression in the lamina cribrosa, optic nerve, ganglion cell layer, inner nuclear layer, outer nuclear layer and retinal pigment epithelium.
Interacts with mitochondrial protein PIGBOS1 (via C-terminus); the interaction occurs at the mitochondria-associated endoplasmic reticulum (ER) membrane, a zone of contact between the ER and mitochondrial membranes, but does not appear to play a role in ER-mitochondria tethering and is not affected by ER stress. Interacts with CALR.
Belongs to the chloride channel MCLC family.
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