CLIC3 Antibody - #DF3935
| Product: | CLIC3 Antibody |
| Catalog: | DF3935 |
| Description: | Rabbit polyclonal antibody to CLIC3 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Dog |
| Mol.Wt.: | 27 KD; 27kD(Calculated). |
| Uniprot: | O95833 |
| RRID: | AB_2836288 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF3935, RRID:AB_2836288.
Fold/Unfold
2300003G24Rik; Chloride intracellular channel 3; Chloride intracellular channel protein 3; MGC109225; OTTHUMP00000022630;
Immunogens
Detected in placenta (at protein level). Widely expressed. High expression is found in placenta followed by lung and heart. Low expression in skeletal muscle, kidney and pancreas.
- O95833 CLIC3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAETKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRSPDVLKDFAPGSQLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFHKFSAFIKNPVPAQDEALYQQLLRALARLDSYLRAPLEHELAGEPQLRESRRRFLDGDRLTLADCSLLPKLHIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYTCPHSAEILAAYRPAVHPR
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O95833 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S49 | Phosphorylation | Uniprot | |
| K54 | Ubiquitination | Uniprot | |
| Y128 | Phosphorylation | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| Y229 | Phosphorylation | Uniprot |
Research Backgrounds
Can insert into membranes and form chloride ion channels. May participate in cellular growth control.
Nucleus. Membrane>Single-pass membrane protein. Cytoplasm.
Note: Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity).
Detected in placenta (at protein level). Widely expressed. High expression is found in placenta followed by lung and heart. Low expression in skeletal muscle, kidney and pancreas.
Associated with the C-terminal of MAPK15.
Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).
Belongs to the chloride channel CLIC family.
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